The effect of oral administration of Folus (Cassia fistula( fruit aqueous extract on abomasal emptying rate in neonatal lambs

Subject Areas : Veterinary Clinical Pathology

Mostafa Abdollahi ¹ , Hamidreza Mohammadi ² , Mahmood Ahmadi Hamedani ³ , Morteza Abdollahi ⁴ , Vahid Shahbazi ⁵

1 - Post Graduate Student of Large Animals Internal Medicine, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
2 - Asistant Professor, Department of Clinical Science, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
3 - Asistant Professor, Department of Clinical Science, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
4 - DVM Graduate, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran.
5 - DVM Graduate, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.

Received: 2018-04-10 Accepted : 2018-11-04 Published : 2019-04-21

Keywords: lamb, Spectrophotometry, Abomasum, Cassia fistula fruit,

Abstract :

Abomasal hypomotility plays an important role in the pathogenesis of certain abomasal disorders such as abomasal bloat. Serious side effects such as diarrhea and antibiotic resistance are associated with using synthetic drugs for treatment of these disorders and administration of herbal medicine could be an appropriate approach to decrease these side effects. Therefore the goal of this study was to evaluate the effect of Folus fruit aqueous extracton abomasal emptying in lambs. This study was conducted on twelve five-day-old Sangsari-female-lambs (average weight 4 kg). Lambs received five oral treatments including saline (30 ml), erythromycin (400 mg) and folus at three different doses (700, 750 and 800 mg/kg) respectively. Acetaminophen absorption test was used to evaluate the rate of abomasal emptying. After drawing the association curve  between plasma acetaminophen concentration and time using the regression method, it was indicated that treatment with erythromycin and three different doses of aqueous extract of folus fruit (700, 750, 800 mg/kg) significantly increased the rate of abomasal emptying in comparison to the negative control (p < /em><0.05). No clinical side effects were observed following the administration of erythromycin and folus in lambs. This study showed that aqueous extract of folus fruit has a stimulatory effect on abomasal emptying in lambs but further studies are required to determine the effects of various components of this plant on abomasal emptying.

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