The Effect of 8 weeks of Concurrent Training on Plasma Concentration of Irisin and BDNF in Overweight Middle-Aged Men

Subject Areas : Sports Science and Healthy

Zohre Koohkheil ¹ , Davar Khodadadi ^{2 *} , Parham Jalali ³

1 - Master's Student, Faculty of Physical Education and Sports Sciences, Karaj Branch, Islamic Azad University, Karaj, Iran.
2 - Assistant Professor, Department of Physical Education and Sports Sciences, West Tehran Branch, Islamic Azad University, Tehran, Iran
3 - BA., Department of Physical Education and Sports Sciences, West Tehran Branch, Islamic Azad University, Tehran, Iran.

Received: 2023-05-30 Accepted : 2023-06-25 Published : 2022-12-22

Keywords: Middle Aged Men, overweight, Irisin, Plasma BDNF.h, Concurrent training,

Abstract :

The purpose of the present study is to review the effect of 8 weeks of concurrent training on plasma concentration of Irisin and Brain-Derived Neurotrophic Factor (BDNF) in overweight middle-aged men.20 healthy middle-aged men with the average age of 51.3±7.5 were randomly chosen and divided into 2 groups of test (10 members) and control (10 members) groups. The participants in the test group took part in 8 weeks of concurrent exercise. The work out plan consisted of 10 minutes of warm-up, 25 minutes of aerobics, 30 minutes of endurance activities, and 5 minutes of cool-down. Blood samples were tested before the test and 48 hours after the last work out session in order to measure Irisin and BDNF levels by ELISA test. For data analysis, t-test was used. The results showed that plasma concentration of Irisin and BDNF levels increased significantly in the test group compared to the pre-test (P≥ 0.001). Also, the comparison between test group and control group in post-test indicated high plasma levels of Irisin and BDNF in the concurrent test group (P≥ 0.001). Furthermore, there was a significantly positive relation between plasma changes of Irisin and BDNF (r-0.569; P≥ 0.01).  It seems that concurrent exercising can positively regulate Irisin and BDNF levels in overweight middle-aged men and thus fight against the harmful effects of aging.

References:

برادران، حبیب؛ رحمانی‌نیا، فرهاد؛ علمیه، علیرضا (1399). اثر هشت هفته تمرینات ترکیبی (هوازی و مقاومتی) بر سطوح سرمی آیریزین و لپتین در مردان دارای اضافه وزن. دانشور پزشکی، 28(4)، ص 22-10.

 

 

Allen, S.J., Watson, J.J., Shoemark, D.K., Barua, N.U. & Patel, N.K. (2013). GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacology & therapeutics, 138(2), p.155-175.

Baker, L.D., Bayer-Carter, J.L., Skinner, J., Montine, T.J., Cholerton, B.A., Callaghan, M. & et al.  (2012). High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment. Journal of Alzheimer's Disease, 28(1), p.137-146.

Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C. & et al.  (2014). Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. International journal of obesity, 38(5), p.707-713.

Boström, P., Wu, J., Jedrychowski, M.P., Korde, A., Ye, L., Lo, J.C. & et al. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), p.463-468.

Castillo-Quan, J.I. (2012). From white to brown fat through the PGC-1 _ depend-ent myokine irisin: implications for diabetes and obesity. Dis Model Mech, 5, p.293–5.

Chen, K., Wang, K. & Wang, T. (2022). Protective effect of irisin against Alzheimer’s disease. Frontiers in Psychiatry, No.13.

Colcombe, S. & Kramer, A.F. (2003). Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychological science,14(2), p.125-130.

Danaei, G., Ding, E.L., Mozaffarian, D., Taylor, B., Rehm, J., Murray, C.J. & Ezzati, M. (2009). The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS medicine, 6(4).

De la Rosa, A., Olaso-Gonzalez, G., Arc-Chagnaud, C., Millan, F., Salvador-Pascual, A., García-Lucerga, C. & et al.  (2020). Physical exercise in the prevention and treatment of Alzheimer's disease. Journal of sport and health science, 9(5), p.394-404.

Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A. & Ruppenthal, S. & et al. (2013). Irisin and exercise training in humans – results from a randomizedcontrolled training trial. BMC Med,11, p.235.

Hillman, C.H., Erickson, K.I. & Kramer, A.F. (2008). Be smart, exercise your heart: exercise effects on brain and cognition. Nature reviews neuroscience,9(1), p.58-65.

Jodeiri Farshbaf, M., Ghaedi, K., Megraw, T.L., Curtiss, J., Shirani Faradonbeh, M., Vaziri, P. & Nasr-Esfahani, M.H. (2016). Does PGC1α/FNDC5/BDNF elicit the beneficial effects of exercise on neurodegenerative disorders? Neuromolecular medicine, 18, p.1-15.

Lebrun, B., Bariohay, B., Moyse, E., Jean, A. (2006). Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. Autonomic neuroscience: basic & clinical,126-127, p.30-8.

Lecker. S.H., Zavin, A., Cao, P., Arena, R., Allsup, K., Daniels, K.M. & et al. (2012). Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ Heart Fail, 5, p. 812–8.

Liang, K.Y., Mintun, M.A., Fagan, A.M., Goate, A.M., Bugg, J.M., Holtzman, D.M. & et al.  (2010). Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of neurology, 68(3), p.311-318.

Maaike Goekinta, B. & et al. (2010). Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor? Neuroscience letters,486(13), p.146-9.

Morris, J.C. & Price, A.L. (2001). Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J Mol Neurosci,17, p.101-118.

Qi, J.Y., Yang, L.K., Wang, X.S., Wang, M., Li, X.B., Feng, B. & et al. (2022). Mechanism of CNS regulation by irisin, a multifunctional protein. Brain Research Bulletin, vol. 188, p. 11-20. https://doi.org/10.1016/j.brainresbull.2022.07.007

Scharhag-Rosenberger, F., Meyer, T., Wegmann, M., Ruppenthal, S., Kaestner, L., Morsch, A. & Hecksteden, A. (2014). Irisin does not mediate resistance training-induced alterations in resting metabolic rate. Medicine and science in sports and exercise, 46(9), p.1736-1743.

Tsai, C.L., Pan, C.Y., Tseng, Y.T., Chen, F.C., Chang, Y.C. & Wang, T.C. (2021). Acute effects of high-intensity interval training and moderate-intensity continuous exercise on BDNF and irisin levels and neurocognitive performance in late middle-aged and older adults. Behavioural brain research,10(413), p.113472.

Wrann, C.D., White, J.P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J. & et al. (2013). Exercise induces hippocampal BDNF through a PGC- 1alpha/FNDC5 pathway. Cell Metabolism, 18, p. 649-59.

Zhang, Y., Zhang, X. & Lin, S. (2022). Irisin: A bridge between exercise and neurological diseases. Heliyon, e12352.