Structural and Biological properties of Hydroxyapatite scaffold coated with poly (Lactic-co-glycolic) containing Ag doped CuO

Subject Areas : Journal of Nano Chemistry and Electrochemistry

Hossein Abbastabar Ahangar ¹

1 - Department of chemistry, Advanced Materials Research Center,Najafabad Branch Islamic Azad university

Received: 2021-06-04 Accepted : 2021-07-20 Published : 2021-09-23

Keywords: Antibacterial, CuO, Bone tissue, Hydroxy apatite,

Abstract :

Introduction:
In bone tissue engineering, bone infections due to trauma, congenital malformations, bone tumors, and accidental crushing can be repaired to restore damaged tissue and restore normal function of lost or damaged tissue. Therefore, the use of antibacterial coatings in porous scaffold for use in implants has been developed in recent years. Hydroxyapatite with suitable biological properties can be one of the suitable materials for making porous bodies.
Material and method:
In this paper, the effect of Ag doped CuO nanoparticles on antibacterial behavior of hydroxyapatite- Poly lactic-co-glycolic acid scaffold was studied. The synthesized composite was characterized by X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectra. A gram-positive and a gram-negative bacteria are used to assess the disk's antibacterial activity and the disk exhibits acceptable activity against both of them
Results:
The obtained results showed that Poly lactic-co-glycolic acid-Hydroxyapatite scaffold did not make inhibition zone in culture medium but the modification of Hydroxyapatite- Poly lactic-co-glycolic acid scaffold’s surface by Ag doped CuO led to the higher antibacterial inhibition zone of 19 and 29 mm for Escherichia coli and Staphylococcus aureus, respectively.
Discussion and conclusion:
The highest antibacterial properties were observed by scaffolds modified with Ag doped CuO. These modified scaffolds have good potential for use in bone tissue engineering, including anti-infective applications.