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Manuscript ID : JMW-2212-2046 (R1) Visit : 125 Page: 29 - 41

10.30495/jmw.2023.1975431.2046

Article Type: Original Research

Preparation, structural characterization, and study on antibiofilm properties of quercetin-barium phosphate nanofibers

Subject Areas : Medical Microbiology

Somayeh  Mojtabavi 1 (Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran)
Khashayar  Vojdanitalab 2 (Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran)
Manica  Negahdaripour 3 (Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran)
Mohammad-Reza  Delnavazi 4 (Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran)
Mohammad Ali  Faramarzi 5 (Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran)

Received: 2022-12-09 Accepted : 2023-05-11 Published : 2023-06-05

Keywords: Nanofiber, Quercetin, Keywords: Biofilm, Hybrid structure,

Abstract :

Background & Objectives: The spread of drug resistance and limited effects of antibiotics on the pathogenic biofilms along with the increasing number of hospital infections have imposed heavy costs on the healthcare system. In the present study, quercetin-barium phosphate hybrid nanostructures were fabricated and characterized in order to improve their antibiofilm activity. Materials and methods: To prepare hybrid nanostructures, barium sulfate was added to sodium phosphate buffer containing quercetin (0.1 mg mL–1), the reaction mixture was sonicated for 10 min, and the obtained precipitate was collected. To obtain the hybrid nanostructures with the maximum immobilized quercetin, the concentrations of phosphate buffer and barium sulfate were examined in the range of 50–250 mM and 10–50 mM, respectively. The prepared hybrid nanostructures were characterized using scanning electron microscopy, infrared spectroscopy, and X-ray diffraction analysis, their effects were evaluated in preventing and destroying bacterial biofilms as well. Results: The immobilization yield of quercetin within hybrid structures was 95%. The scanning electron microscope images showed fiber-like structures with smooth, knot-free, and uniform surfaces. Quercetin-barium phosphate hybrid nanofibers significantly inhibited the biofilm formation in Pseudomonas aeruginosa and Staphylococcus aureus by 100% and 80%. Also, in the presence of the immobilized quercetin (500 mg L–1), biofilms of Staphylococcus aureus and Bacillus subtilis were destroyed by 75% and 70%. Conclusion: Due to the notable antibiofilm properties of quercetin-barium phosphate hybrid nanofibers, they could be useful in medical devices, and therapeutic and environmental processes.

References:


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22. Singh AK, Yadav S, Sharma K, Firdaus Z, Aditi P, Neogi K, Bansal M, Gupta MK, Shanker A, Singh RK, Prakash P. Quantum curcumin mediated inhibition of gingipains and mixed-biofilm of Porphyromonas gingivalis causing chronic periodontitis. RSC Adv. 2018; 8(70): 40426–45.

_||_

  1. Wang Y, Tao B, Wan Y, Sun Y, Wang L, Sun J, Li C. Drug delivery based pharmacological enhancement and current insights of quercetin with therapeutic potential against oral diseases. Biomed Pharmacother. 2020; 128: 110372.
    2.
  2. Salehi B, Machin L, Monzote L, Sharifi-Rad J, Ezzat SM, Salem MA, Merghany RM, El Mahdy NM, Kılıç CS, Sytar O, Sharifi-Rad M. Therapeutic potential of quercetin: New insights and perspectives for human health. Acs Omega. 2020; 5(20): 11849–72.
    3.
  3. Liu Y, Ji X, He Z. Organic–inorganic nanoflowers: from design strategy to biomedical applications. Nanoscale. 2019; 11(37): 17179–94.
    4.
  4. Arasoğlu T, Derman S, Mansuroğlu B, Uzunoğlu D, Koçyiğit BS, Gümüş B, Acar T, Tuncer B. Preparation, characterization, and enhanced antimicrobial activity: quercetin-loaded PLGA nanoparticles against foodborne pathogens. Turk J Biol. 2017; 41(1): 127–40.
    5.
  5. Kiani M, Mojtabavi S, Jafari-Nodoushan H, Tabib SR, Hassannejad N, Faramarzi MA. Fast anisotropic growth of the biomineralized zinc phosphate nanocrystals for a facile and instant construction of laccase@ Zn3(PO4)2 hybrid nanoflowers. Int J Biol Macromol. 2022; 204: 520–31.
    6.
  6. Fathali Z, Rezaei S, Faramarzi MA, Habibi-Rezaei M. Catalytic phenol removal using entrapped cross-linked laccase aggregates. Int J Biol Macromol. 2019; 122: 359–66.
    7.
  7. Jafari-Nodoushan H, Mojtabavi S, Faramarzi MA, Samadi N. Organic-inorganic hybrid nanoflowers: The known, the unknown, and the future. Adv Colloid Interface Sci. 2022; 102780.
    8.
  8. Emami S, Foroumadi A, Faramarzi MA, Samadi N. Synthesis and antibacterial activity of quinolone‐based compounds containing a coumarin moiety. Arch Pharm. 2008; 341(1): 42–8.
    9.
  9. Machado IE, Prado L, Gomes L, Prison JM, Martinelli JR. Optical properties of manganese in barium phosphate glasses. J Non-Cryst Solids. 2004; 348: 113–7.
    10.
  10. Shokri M, Mojtabavi S, Jafari-Nodoushan H, Vojdanitalab K, Golshani S, Jahandar H, Faramarzi MA. Laccase-loaded magnetic dialdehyde inulin nanoparticles as an efficient heterogeneous natural polymer-based biocatalyst for removal and detoxification of ofloxacin. Biodegradation 2022; 33(5): 489–508.
    11.
  11. Rezayaraghi F, Jafari-Nodoushan H, Mojtabavi S, Golshani S, Jahandar H, Faramarzi MA. Hybridization of laccase with dendrimer-grafted silica-coated hercynite-copper phosphate magnetic hybrid nanoflowers and its application in bioremoval of gemifloxacin. Environ Sci Pollut Res. 2022; 29(59): 89255–72.
    12.
  12. Mojtabavi S, Khoshayand MR, Torshabi M, Gilani K, Fazeli MR, Faramarzi MA, Samadi N. Formulation, characterization, and bioactivity assessments of a laccase-based mouthwash. J Drug Delivery Sci Technol. 2022: 69: 103128.
    13.
  13. Mojtabavi S, Khoshayand MR, Fazeli MR, Faramarzi MA, Samadi N. Development of an enzyme-enhancer system to improve laccase biological activities. Int J Biol Macromol. 2021; 173: 99–108.
    14.
  14. Vojdanitalab K, Jafari-Nodoushan H, Mojtabavi S, Shokri M, Jahandar H, Faramarzi MA. Instantaneous synthesis and full characterization of organic–inorganic laccase-cobalt phosphate hybrid nanoflowers. Sci Rep. 2022; 12(1): 1–6.
    15.
  15. Khan MA, Zhou C, Zheng P, Zhao M, Liang L. Improving physicochemical stability of quercetin-loaded hollow zein particles with chitosan/pectin complex coating. Antioxidants. 2021; 10(9): 1476.
    16.
  16. Hariri P, Jafari-Nodoushan H, Mojtabavi S, Hadizadeh N, Rezayaraghi F, Faramarzi MA. Magnetic casein aggregates as an innovative support platform for laccase immobilization and bioremoval of crystal violet. Int J Biol Macromol. 2022; 202: 150–60.
    17.
  17. Scalia S, Mezzena M. Incorporation of quercetin in lipid microparticles: Effect on photo-and chemical-stability. J Pharm Biomed Anal. 2009; 49(1): 90–4.
    18.
  18. Yu XN, Qian CX, Wang X. Bio-inspired synthesis of barium phosphates nanoparticles and its characterization. Dig J Nanomater. Biostructures 2015; 10: 199–205.
    19.
  19. Barreto AC, Santiago VR, Mazzetto SE, Denardin JC, Lavín R, Mele G, Ribeiro ME, Vieira IG, Gonçalves T, Ricardo NM, Fechine PB. Magnetic nanoparticles for a new drug delivery system to control quercetin releasing for cancer chemotherapy. J Nanopart Res. 2011; 13(12): 6545–53.
    20.
  20. Vashisth P, Nikhil K, Pemmaraju SC, Pruthi PA, Mallick V, Singh H, Patel A, Mishra NC, Singh RP, Pruthi V. Antibiofilm activity of quercetin-encapsulated cytocompatible nanofibers against Candida albicans. J Bioact Compat Polym. 2013; 28(6): 652–65.
    21.
  21. Kim MK, Lee TG, Jung M, Park KH, Chong Y. In vitro synergism and anti-biofilm activity of quercetin–pivaloxymethyl conjugate against Staphylococcus aureus and Enterococcus Species. Chem Pharm Bull. 2018; 66(11): 1019–22.
    22.

22. Singh AK, Yadav S, Sharma K, Firdaus Z, Aditi P, Neogi K, Bansal M, Gupta MK, Shanker A, Singh RK, Prakash P. Quantum curcumin mediated inhibition of gingipains and mixed-biofilm of Porphyromonas gingivalis causing chronic periodontitis. RSC Adv. 2018; 8(70): 40426–45.

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