Skin drug release and antifungal activity of econazole-containing silica nanoparticles

Subject Areas : Mycology

maryam montazeri ¹ , Saman Ahmad Nasrollahi ² , Alireza Feizbakhsh, ³ , , Mehdi Razzaghi-Abyaneh ⁴

1 - IAU, Central Tehran Branch, Department of Chemistry, Tehran, Iran
2 - Tehran University of Medical, Nanodermatology Unit, Center for Research & Training in Skin Diseases & Leprosy, Sciences, Tehran, Iran
3 - Islamic Azad University, Central Tehran Branch, Department of Chemistry, Tehran, Iran
4 - Pasteur Institute of Iran

Received: 2020-04-26 Accepted : 2020-09-13 Published : 2020-11-21

Keywords: Antifungal activity, Silica nanoparticles, Keywords: Econazole, targeted drug delivery,

Abstract :

Background & Objectives: Silica Nanoparticles (MCM41) are silica mesopores (MSNs), which have large pores and relatively low density. The purpose of this study was to load Econazole onto silica nanoparticles (MCM41-NH2 and MCM41) And release of econazole in human skin (Ex-Vivo) then the antifungal effect of loaded econazole on silica nanoparticles was investigated. Materials & Methods: In this study, MCM41 was prepared, then MCM41-NH2 nanoparticles were provided by using amine cetyltrimethylammonium bromide and finally, the drug econazole was loaded on it. The morphology of the nanoparticles was determined by SEM and drug loading by FT-IR. Francescell and UV-Vis were used to measure the release. The release cream from the skin containing 1/1 drug and nanoparticles was prepared. Finally, the anti-fungal effect of ECO/MSNs was investigated in three ways. Francescell device was also used to check skin release. Results: Silica nanoparticles were prepared about 300 nanometers Release of the drug into the skin showed that during the first 8 hours 80% release and then up to 24 hours of continuous drug release. Antifungal effect by disk diffusion method showed that ECO/MCM41 had a larger inhibitory effect and also minimal inhibition of fungal growth (MIC) 75 mg/ml. Antifungal tests showed that no fungus grew after 72 hours.the antifungal effect as well as ECO / MCM41 (MIC) was greater in methanol. Conclusion: The antifungal effect of the newest agar method was not suitable for this drug. Therefore, as a suitable drug in the cream, a drug loaded with methanol is recommended.

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