Investigating the effect of vitamin D serum level on egg maturation and embryo quality in the process of treating patients with polycystic ovary syndrome (PCOS) by using quercetin.
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms
sima vaez
1
,
Kazem Parivar
2
,
Fardin Amidi
3
,
nasim HAYATI ROODBARI
4
,
Ashraf Moeini
5
1 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Biology, Science and Research
Branch, Islamic Azad University, Tehran, Iran
3 - Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
5 - Department of Gynecology and Obstetrics, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Quercetin, polycystic ovary syndrome, PCOS, vitamin D,
Abstract :
Polycystic ovary syndrome is a common reproductive disease, which has a high prevalence in women of reproductive age. Quercetin is a natural compound of flavonoids that can intervene in the pathological process of PCOS. The aim of this study is to investigate the effect of quercetin in PCOS patients on egg maturation in IVF patients. Also, the effect of reducing vitamin D in this process was investigated. The patients in this study were divided into two groups: the first group was the control group used only placebo without any information and the second group was the experimental group that used quercetin. Each of them received one oral capsule (medicine or placebo) daily for about forty days from the beginning of a cycle before the ovulation stimulation cycle until the day of ovulation. At the end, the level of egg maturation and embryo quality and serum level of LH, FSH and AMH were investigated. Vitamin D serum level was also analyzed. The results showed that there is a significant difference in egg grade and embryo quality in both control and drug groups. There was no significant difference in the level of LH, FSH and AMH between the control and drug groups. Also, in the group that took quercetin, embryo quality and egg maturation have a direct relationship with vitamin D levels. Conclusion: Quercetin plays an important role in egg maturation and embryo quality, which is directly related to the serum level of vitamin D in PCOS patients who underwent IVF treatment.