Comparison of the effect of watery and alcoholic Celery ( Apium graveolens) extraction on the growth of Aspergillus flavus,Trichophyton rubrum and Candida albicans : in vitro

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

robab ebrahimibarough ¹ , seyed jamal hashemi ² , roshanak daei ³ , Sadegh Khodavisi ⁴ , peghah ardi ⁵ , shima parsay ⁶

1 - tehran university of medical sciences
2 - Professor of medical mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3 - Associate professor Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4 - assistant professor, Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5 - M.Sc. student, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
6 - school of public health, tehran university of medical sciences, tehran, iran

Received: 2019-09-16 Accepted : 2020-01-19 Published : 2020-01-21

Keywords: Candida albicans, Aspergillus flavus, watery and alcoholic extract of of Apium graveolens, Trichophyton rubrum,

Abstract :

Nowadays, a large number of antifungal drugs are produced in the world, but the main issue of drug resistance to these treatments is BASHDV, therefore, new findings or materials that have antifungal effect have always been considered for researchers in different fields.Therefore, this study the antifungal effects of celery extract on the yeast fungi of Candida albicans, Dermatophyte (Trichophyton rubrum) and sproblons (Aspergillus flavus) have been investigated in laboratory conditions. In this experimental study, watey and alcoholic extracts of celery were prepared by maceration method.Antifungal activity of alcoholic and watery extract of the celery plant was evaluated using application diffusion in disk and well diffusion for 3 types of Aspergillus flavus, Trichophyton, and Candida albicans with three replications. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MFC) by Microdilishin method were determined. The results were analyzed using one-way anova. The results showed that the alcoholic extract of the celery plant in comparison with the watery extract has a more inhibitory effect on the laboratory conditions. As a result, the alcoholic extract of the celery plant has a greater antifungal effect.