Evaluation of healing effect of clove nanofibers in comparison with poly-caprolactone nanofibers in experimental skin wounds

Subject Areas : Journal of Comparative Pathobiology

M. Ashjazadeh, ¹ , A. Jahandideh, ^{2 *} , G. Abedi, ³ , A. Akbarzadeh, ⁴ , S. Hesaraki, ⁵

1 - Department of Clinical Science, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Clinical Science, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Clinical Science, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5 - Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Received: 2022-02-23 Accepted : 2022-02-23 Published : 2021-08-23

Keywords: Nanofibers, Clove, Repair, Polycaprolacton,

Abstract :

To date, the anti-inflammatory and antimicrobial effect of clove extract has been proven, which makes it one of the treatments that can be used in wound healing. Comparing the healing effect with other healing aids makes clove extract stand out among wound healers. In this study, histopathological examination of clove nanofibers (eugenol) was performed in comparison with polycaprolactone nanofibers in other experimental thicknesses created in rat skin. In 45 adult Wistar rats, a dorsal ulcer induced. They are then randomly divided into three groups of 15 (observed group, eugenol nanofibers and polycaprolactone), then each into five other groups of 5 (fraternity sample groups on days seven, 14, and 21) Divide, collagen, epithelial thickness, scar, leukocytes infiltration, edema, acute hemorrhage and stretch test were evaluated. In the eugenol treatment group, epithelialization and collagen index increased significantly (P <0.05) from days 7 to 21 from the other two budget groups. The results show that clove nanofibers accelerated the healing process in thickened skin function compared to polycaprolactone and the control group.

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