Experimental study of ethanolic extract of brown algae Nizimuddinia zanardinii on liver histopathological injury induced by bile duct ligation inrats
Subject Areas : Journal of Comparative Pathobiology
مدارا Nasiri
1
(Department of Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran)
, M Ale-Ebrahim
2
(Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran)
, R Hajikhani
3
(Department of Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.)
, P Mortazavi
4
(Department of Pathology, Faculty of Specialized Veterinary, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Keywords: Bile duct ligation, Cholestasis, Liver fibrosis, Brown algae, Nizimuddiniazanardinii,
Abstract :
liver fibrosis has been recognized as a cause of morbidity and mortality in humans. The oxidative stress in cholestaticliver disease serves as a link between hepatic injury and liverfibrosis. Therefore, any agent that has the capacity of normalizing the oxidative damage, would be able to decrease fibrosis in a cholestatic liver. The brown Algae Nizimuddiniazanardiniiis one of the natural resources in the marine ecosystem which contains biologically activecompoundsand it's anti-inflammatory, anti-cancer, anti-fungal and antioxidant effects are known.The aim of the present study was the evaluation of the effect of ethanolicextract of brownalgaeNizimuddiniazanardinii on liverfibrosis induced by bileductligation (BDL) in malerats. 54 male rats were randomly classified in nine groups (n=6): control group (intact rats), sham group (laparatomy without BDL),Nizimuddinia extract control groups (50,100 or 200mg/kg). BDL group, experimental treatment groups (BDL rats+50,100 or 200mg/kg Nizimuddinia). BDL increased the serumlevels of aspartateaminotransferase, alanineaminotransferase, alkalinephosphatase, totalbilirubin, cholesterol and triglyceride, whereas it reduced the levels of antioxidantenzymes, superoxidedismutase and catalase in the liver and also reduced the serumic levels of albumin and total protein. Treatment of BDL rats with Nizimuddiniazanardiniiextract attenuated these changes. As determined by Masson’s trichrome staining, BDL markedly induced the liverfibrosis. These alterations were also significantly attenuated by Nizimuddiniazanardiniiadministration. The results of this study indicate the hepatoprotective and antifibrotic effect of Nizimuddiniazanardiniiin the cholestatic liver. The antifibrotic effect of this brown algea likely due to the antioxidative and freeradical scavenging effects of it.
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