Gastrointestinal motility ablative effect of methanol extract of L. hyssopifolia in diarrhoea due to caster oil and 5-HT in mice

Subject Areas : Journal of Comparative Pathobiology

ایلیاد  عیسی بیگلو ¹ (ندارد)
محمدتقی  زادیه ² (ندارد)

Received: 2011-06-25 Accepted : 2011-11-10 Published : 2012-02-20

Keywords: L. hyssopifolia, diarrhoea, caster oil, 5-HT, mice,

Abstract :

Diarrhoea is one of the most important GI tract that reduces meaningful performance of thepatient. Dried whole plant parts of Ludwigia hyssopifolia were subjected to successive coldextraction with n-hexane, ethylacetate and methanol. The methanol extract (LHM), obtained as1% yield, showed significant antidiarrheal property by reducing diarrheal episodes in castor oiland serotonin induced diarrhea in laboratory mice at a dose of higher than 100mg/kg bodyweight as compared to standard drug loperamide given at a dose of 66.67 μg/kg body weight.The percent reduction in diarrheal episode by 56.32 and 89.66 after castor oil challenge and59.09 and 86.36 in serotonin induced diarrhea was observed at doses of 200mg/kg and400mg/kg body weight of the extract respectively. The extract LHM was also found to reducethe gastrointestinal motility by 53.8% at a dose of 100mg/kg body weight as compared tocontrol, while no remarkable inhibition of gastrointestinal motility was seen at a dose of50mg/kg body weight of the extract.