Evaluation of carbapenem family antibiotic consumption patterns for controlling common bacterial infections in hospital

Subject Areas : Journal of Comparative Pathobiology

mohammad mehdi rashidi ¹ (Institute of Energy Studies, Tehran, Iran)
Seyed Reza Abtahi ² (Department of Pharmacology and Toxicology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran)
فرشاد Nojoomi ³ (Associate Professor of Microbiology, School of Medicine, Infectious Diseases Research Center, AJA University of Medical Sciences, Tehran, Iran)
ایرج Mirzaii Dizgah ⁴ (Professor of Physiology, School of Medicine, Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran)
محمد Darvishi ⁵ (Associate Professor of Infectious Disease, School of Aerospace and Subaquatic Medicine, Infectious Diseases Research Center, Beasat Hospital, AJA University of Medical Sciences, Tehran, Iran. )

Received: 2024-03-05 Accepted : 2024-04-24 Published : 2024-03-05

Keywords: Drug consumption pattern, Carbapenems, Meropenem, Imipenem, Intensive care units.,

Abstract :

Antibiotic resistance is a global concern due to the irrational use of antibiotics. Patients hospitalized in intensive care units are exposed to antibiotic resistance due to their high vulnerability. Therefore, this study was performed to investigate the pattern of carbapenem consumption in the intensive care units of Besat Hospital in a period of six months. This study was conducted by studying the records of patients from March 2018 to September 2018 and extracting hospital statistics from the medical records keeping unit and extracting drug consumption data from the pharmacological statistics unit. Occupied bed-day were obtained from the information classification system of the medical records unit and carbapenem consumption statistics from the pharmacological information system. According to evaluation methods of the medicines, the carbapenem use was expressed as DDD/100 bed-day. In total, 203 patients were admitted to intensive care units. The most common cause of carbapenem use was pneumonia (47.8%). In total, 4928.5 grams of meropenem (equivalent to 25.319 in terms of DDD/100 bed-day) and 79.5 grams of imipenem (equivalent to 0.612 in terms of DDD/100 bed-day) were used. From a total of 709 microbial cultures, sensitivity to carbapenems was investigated in only 145 cases (20.45%). 26 cases (17.93%) had sensitivity and 119 cases (82.07%) had resistance to at least one carbapenem (meropenem and imipenem). Acinetobacter baumannii was highly prevalent. Moreover, the consumption of meropenem and imipenem was high. Therefore, there is a need to adhere to the antibiotic monitoring policy for the appropriate use of antibiotics.

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