The effect of oral administration of D-penicillamine on electrocardiogram parameters in pekin ducks poisoned with lead nitrate
Subject Areas : Journal of Comparative Pathobiologyhamed zarei 1 , Abdollah Kashani 2 , Azin Tavakoli 3
1 - Assistant Professor, Department of Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Department of Animal Sciences, Faculty of Agriculture, Garmsar Branch, Islamic Azad University, Garmsar, Iran
3 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
Keywords: D-penicillamine, Electrocardiography, Lead, Pekin duck,
Abstract :
Lead is known as one of the most important environmental pollutants for the body. The aim of this study is to evaluate the effect of oral administration of D-penicillamine on electrocardiogram parameters in ducks poisoned with lead nitrate. The number of 90 Pekin ducks divided into three groups of 30 including the negative control group, the positive control group (40 mg/kg of lead nitrate in the diet), and the treatment group (lead nitrate at a dose of 40 mg/kg + D-penicillamine at a dose of 20 mg/kg kg in the diet). In order to measure the height of the T, S, R complex components and the ST, RR, QT, QRS intervals and the electrical axis of the heart at the ages of 28 and 60 days, electrocardiogram strips were prepared from 8 chickens in each group. In the positive control group, the height of R, S, and T waves increased significantly compared to the negative control group (P<0.05). D-penicillamine prevented the abnormal increase of these waves in the treated groups, so that this reduction was significant in 60 days in the S wave of derivation III and aVF and the T wave in derivations II, III, aVF and aVR (P<0.05). Also, QRS and QT intervals increased significantly in some derivatives of the positive control group (P<0.05). In the group treated with D-penicillamine, no significant increase in these parameters was observed, so that this lack of increase in the QRS interval in lead II and aVF and in the ST interval of lead III was significant (P<0.05) at 60 days. Finally, it seems that the oral administration of D-penicillamine leads to the improvement of heart electrocardiogram indices in ducks suffering from lead nitrate poisoning.
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