Influence of process parameters on the preparation of porous calcium phosphate granules by rotary oil method

Subject Areas :

مهدی امیر آبادی فراهانی ¹ , زهرا محمدی ^{2 *} , عبدالرضا شیخ مهدی مسگر ^{3 *}

1 - کارشناس ارشد مهندسی پزشکی (بیومتریال)، آزمایشگاه بیوسرامیک و ایمپلنت، گروه مهندسی علوم زیستی، دانشکده علوم و فنون نوین، دانشگاه تهران، ایران
2 - استادیار، آزمایشگاه بیوسرامیک و ایمپلنت، گروه مهندسی علوم زیستی، دانشکده علوم و فنون نوین، دانشگاه تهران، ایران
3 - استادیار، آزمایشگاه بیوسرامیک و ایمپلنت، گروه مهندسی علوم زیستی، دانشکده علوم و فنون نوین، دانشگاه تهران، ایران

Received: 2017-08-09 Accepted : 2018-05-08 Published : 2018-11-22

Keywords: Porosity, Taguchi Method, Biphasic calcium phosphate, Granule, Spherical particles,

Abstract :

In order to prepare spherical calcium phosphate granules for biomedical applications, several methods have been investigated by the researchers. In this study, the spherical granules with a potential for tissue growth and drug carrying were prepared by a process, known as the rotary oil method, which was based on the hydrophilic and olephobic features of calcium phosphate slurry. This process is a simple and fast method to produce the granules with a controllable size and porosity suitable for different applications in the biomedical field. The process was optimized by Taguchi method using a L9 orthogonal array. Four parameters including stirring rate of oil, oil temperature, needle diameter, and weight ratio of gelatin to water, each of them in three levels, were used. The starting calcium phosphate powder was a calcium- deficient hydroxyapatite which was synthesiezed by an alkaline hydrolysis method. The sintered granules and starting podwer were characterized by XRD and SEM. The rotary oil method produced granules with a size in the range of 120-1580 μm and porosity 35-45% suitable for a range of biomedical applications

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