A review of drug analysis using charge transfer complexes
Subject Areas : Others
1 - Department of Chemistry, Ardabil Branch, Islamic Azad University, Ardabil, Iran
Keywords: charge transfer complex, drug analysis, Electron donor, Electron acceptor,
Abstract :
The charge transfer complex (CTC) is formed by the reaction between electron donor and acceptor and is stabilized by non-covalent interactions. These complexes absorb energy in the ultraviolet or visible region (charge transfer bands). The drug interactions with electron acceptors are important molecular reactions for drug activity. The position and intensity of charge transfer bands of complexes are used to quantify drugs as electron donors. This technique is cheap, simple, and efficient.and many studys have been done in this field. Different π-acceptors have been used in spectrophotometric assays and analysis of many pharmaceutical substances as electron donors. The nature of the complexes was determined by elemental analysis, Infrared spectroscopy, Nuclear magnetic resonance spectroscopy and conductometry. In this study, the types of drugs that have the ability to form charge transfer complexes and also the types of electron acceptors used in the analysis of drugs are reviewed.
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