A novel nanobiosensor based on nickel(II) oxide/graphene oxide/purpald nanocomposite for non-enzymatic glucose determination
Subject Areas : Applications of NanostructuresMojtaba Ghorbani 1 , Aliakbar Tarlani 2 * , Saeed Taghvaei Ganjali 3 , Mersedeh Malekzadeh 4
1 - Department of Chemistry, Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Tehran, Iran.
2 - Department of Chemistry, Islamic Azad University, North Tehran Branch, Postal Code: 1913674711, Tehran, Iran.
3 - Department of Chemistry, Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Tehran, Iran.
4 - Department of Chemistry, Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Tehran, Iran.
Keywords: Cyclic voltammetry, Hydrothermal, Nanostructure. ,
Abstract :
Diabetes is one of the leading causes of death and disability in the world. Non-enzymatic glucose measurement has a significant impact on diabetes control. Diagnosis and management of diabetes requires accurate control of blood glucose levels. In a new approach, nickel(II) oxide nanostructures were synthesized by solvothermal method with the help of bifunctional amino acid lysine and urea additive. Then, nickel(II) oxide nanostructures were loaded on graphene oxide functionalized with Purpald. The above nanocomposite was characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy. In order to construct a new nanobiosensor for glucose detection without the need for glucose oxidase, the prepared nanostructure was placed on a glassy carbon electrode. The sensitivity of the designed nanobiosensor for glucose detrermination was 1.7 μA/cm2 mM at a concentration of 10 mM. Meanwhile, the fabricated glucose sensor showed no interference with dopamine, fructose, and ascorbic acid.
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