Investigation of carbon-carbon coupling reaction by Negishi method using polyvinyl pyrrolidone supported zinc chloride nanopowder and its kinetics study

Subject Areas : Polymers and Organic Structures

Seyed Ali Hosseini Shahrasb ¹ , Setareh Sheikh ^{2 *} , Nooreddin Goodarzian ³

1 - Department of Chemistry, Islamic Azad University, Shiraz Branch, Shiraz, Iran.
2 - Department of Chemistry, Islamic Azad University, Shiraz Branch, Shiraz, Iran.
3 - Department of Chemistry, Islamic Azad University, Shiraz Branch, Shiraz, Iran.

Received: 2024-10-29 Accepted : 2025-01-10 Published : 2025-06-09

Keywords: Heterogeneous catalyst, Cross-coupling, Degree of reaction.,

Abstract :

The creation of new carbon-carbon bonds has great potential in organic syntheses, especially in the field of pharmaceutical synthesis. In this regard, heterogeneous catalysts are the most widely used tools for performing cross-coupling reactions under mild conditions and with high efficiency. In this study, zinc chloride nanopowder stabilized by polyvinyl pyrrolidone have been used as catalysts for the first time. The C-C coupling reaction was studied in Negishi cross-coupling reaction to find out the performance of the proposed catalyst. The results showed that the product yield is satisfactory. Various solvents can be used to use this polymer reagent as a catalyst. Also, the polymer is easy to separate and ultimately can be recovered. In this research, kinetic studies were also conducted on the above reaction, which showed that the reaction follows the third order reaction.

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