Effect of Ellagic Acid on Motor and Memory Disorders induced by 6-OHDA in Male Rats
Subject Areas : Journal of Animal Biology
Z. Eydipour
1
,
M. Rafieirad
2
1 - Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
2 - Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
Keywords: Memory, Parkinson', s disease, ellagic acid, Motion,
Abstract :
Parkinson's disease is a prevalent neuropathological disorder induced due to the degeneration of dopaminergic neurons in the dense part of substantia nigra. Oxidative stress is regarded as the main factor of this disease that causes death of neurons. Considering the protective antioxidative property of ellagic acid, the aim of the present study was to investigate the effect of ellagic acid on motor disorders and memory of animal model of Parkinson's disease. Forty male rats were divided into 5 groups. To create an animal model, the rats received 6-OHDA neural poison with dose of 8 µg in 2 µl of normal saline solution with 0.01% of ascorbic acid inside medial forebrain bundle (MFB) on the left side of the brain. The treatment groups received ellagic acid with doses of 10, 25, and 50 mg/kg for 14 d as gastric gavage and tests were conducted on the rats one day after the last gavage. Ellagic acid improves motor and memory disorders motor disorders and memory resulting from Parkinson's disease particularly at doses 50 mg/kg. Considering the present findings, ellagic acid has a protective effect on 6-OHDA in the experimental model of Parkinson's disease.
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