The Effect of Red Ginseng Water Extract on Oogenesis and Uterus Tissue of Adult NMR Mice

Subject Areas : Journal of Animal Biology

Z. Zohrevand Asl ¹ (Department of Biology, Science and Research Branch, Isamic Azad University, Tehran, Iran)
N. hayati roudbari ² (Department of Biology, Science and Research Branch, Isamic Azad University, Tehran, Iran)
S. Mohamadi Gorji ³ (Department of Biology, Sari Branch, Islamic Azad University, Tehran, Iran)
K. Parivar ⁴ (Department of Biology, Science and Research Branch, Isamic Azad University, Tehran, Iran)

Received: 2017-06-17 Accepted : 2017-06-17 Published : 2017-05-22

Keywords: Oogenesis, Ginseng, Uterus changes, NMRImouse strain,

Abstract :

Herbal product consumption and use of herbal medicines are now the most popular treatment methods. In the meantime, ginseng belongs to the genus Panax of the family Araliaceae has been among top ten common plants in people's food basket. The objective of this study was to evaluate the effect of ginseng extract on oogenesis in the adult NMRI strain. In this experimental study, we randomly divided 30 adult female mouse NMRI strain into 5 groups  for 30 d as follows: 1) Control (not gavaged), 2) Sham (gavaged water), 3) Treatment groups (gavaged 100 mg/kg, 200 mg/kg and 300 mg/kg ginseng extract). Ginseng water extract was prepared in distilled water. After 30 d, they were killed. Ovarian and uterine tissue were removed and studied.The number of primary follicles in three experimental groups was 100, 200 and 300 mg/kg. Secondary follicles with doses of 100 and 200 mg/kg groups and graaf follicle with dose of 200 mg/kg group showed significant increase. Reduction in atretic follicle in groups with doses of 100 and 300 mg/kg was observed. Uterine studies showed significant increase in the thickness of perimeter and endometrial layer in group with dose of 100 mg/kg and the number of glands in experimental groups 1 and 2 showed increased.Finally, wecan say that using red ginseng water extract is effective on oogenesis and uterus tissue.  

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