The Improver Effect of Noscapine in Comparison with Clonazepam on Short-Term Memory in Rat

Subject Areas : Journal of Animal Biology

بیژن Shams ¹

1 - Department of Biology, Payame Noor University, 19395-3697, Falavarjan, Iran

Received: 2018-04-21 Accepted : 2018-04-21 Published : 2018-02-20

Keywords: Morris water maze, Short-term memory, Noscapine, Clonazepam,

Abstract :

Noscapine is one of the opioid alkaloids used as an appropriate cough and reduces the effects of bronchial asthma patients. It has similar effects on benzodiazepines and associated with anxiety and excessive appetite in animal tests. The effect of benzodiazepines is known to reduce memory and cause forgetfulness, especially before the learning phase. Morris water maze is an extensively used as an animal model for studying memory usage. We aimed to evaluate the effect of noscapine on short-term memory in male Wistar rats practiced at the 6th and 7th-day courses in the Morris water maze.The time elapsed and the distance traveled to find the hidden platform was considered as a measure of memory sensitivity. Noscapine (0.5 and 1.5 mg/kg) improves short-term memoryand clonazepam (2 mg/kg) antagonized this effect. Noscapine may facilitate short-term memory. Part of this work can be done by modifying benzodiazepine receptors.

References:

. علیزاده ازدینی، ز.، 1385. بررسی اثر نوسکاپین بر اشتهای مفرط (hyperphagia) در موش کوچک آزمایشگاهی،پایان نامه کارشناسی ارشد، دانشگاه آزاد اسلامی واحد تهران شمال.

2. مبشری، ط.، محمودیان، م.، رستمی، پ.، وزیری فرد،ص.، 1384. تداخل اثر نالوکسون بر فعالیت ضد اضطراب نوسکاپین در موش نر نژاد Balb/c. مجله علوم پایه دانشگاه الزهرا، جلد 18، صفحات 25-32.

3. Belzung C., Guisquet A.M., Griebel G., 2000. Beta-cct, a selective BZ-Omega 1 receptor antagonist, blocks the anti- anxiety but not the amnesic action of chlorodiazepoxide in mice. Behavior and Pharmacology, 11(2): 125-131.

4. Chapouthier G., Venault P., 2002. GABA-A receptor complex and memory processes. Current Topics in Medicinal Chemistry, 2: 841-851.

 

5. Dahlstrom B., Mellstrand T., Losdahl C.G., Johansson M., 1982. Pharmacokinetic properties of noscapine.  European Journal of Clinical Pharmacology, 22: 535-539.

6. De Paula N.C., Araujo Cordeiro K.C., De Melo Souza P.L., Nogueira D.F., Da Silva e Sousa D.B., Costa M.B., Noel F., De Oliveira V., 2015. Biosynthesis of human diazepam and clonazepam metabolites. Bioorganic and Medicinal Chemistry Letters, 25(5):1026-1029.

7. Dhooge R., De Deyn P.P., 2001. Applications of the morris water maze in the study of learning and memory. Brain Research Reviews, 36: 60-90.

8. Ebrahimi S.A., Zareie M.R., Rostami P., Mahmoudian M., 2003. Interaction of noscapine with the bradykinin mediation of the cough response. Acta Physiologica Hungarica,  90: 147-155.

9. Heikkila I., Jalonen J.K., Vartianinen A., 1967. Evaluation of the antitossive effect of noscapine and codein of citric acid induced cough in guinea pigs. Acta Pharmacol Toxicology, 25: 333-336.

10. Hssain I., 2015. Fiche 159-clonazepam (Rivotril): Benzodiazepine anticon vulsivance. Guide Infirmier Des Urgences, 916-917.               

11. Izquierdo I., Medina J.H., 1991. GABAA receptor modulation of memory: The role of endogenous benzodiazepines. Trends In Pharmacological Science, 12: 260-26.

12. Johnson G.A.R., 1996. GABAA receptor pharmacology. Pharmacology and Therapeutics, 69: 173-198.

13. Karlsson M., Dahlstrom B., Aders N., 1988. Characterization of high offinity binding sites. For the antitussive (3H) noscapine in guinea pig brain tissue. European Journal of Pharmacology, 145: 195-203.

14. Ke Y., Ye K., Grossniklaus H.E., Archer D.R., Josh H.C., Kapp J.A., 2000. Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses. Cancer Immunology Immunotherapy Journal, 49(4-5): 217-25.

15. Khodarahmi P., Rostami P., Rashidi A, Khodarahmi I., 2006. Anxiolytic effect of noscapine in mice. Pharmacological Research, 58: 557-568.

16. Kumar B.A., Forster M.J., Lal H., 1988. CGS8216, a benzodiazepine receptor antagonist, enhances learning and memory in mice. Brain Research, 460: 195-198.

17. Mahmoudian M., Mogaverian M., 2001. Effect of noscapine, the antitussive opioid alkaloid,on bradykinin-induced smooth muscle contraction in the isolated ileum of the guinea- pig. Acta Physiologica Hungarica, 88: 231-237.

18. Mahmoudian M., Mehrpour M., Benaissa F., Siadatpour Z., 2003. Apreliminary report on the application of noscapine in the treatment of stroke. European Journal of Pharmacology, 59: 597-581.

19. McKernan R.M., Rosahl T.W., Reynolds D.S., Sur C., Wafford K.A., Atack J.R., Farrar S., Myers J., Cook G., Ferris P., 2000. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype. Natural Neuroscience, 3: 587-592.

20. Nin M.S., Couto-Preira N.S., Souza M.F., Azeredo LA. , Ferri M.K., Dulpra W.L., Gomez R., Barros H.M.T., 2012. Anxiolytic effect of clonazepam in female rats: Grooming microstructure and elevated plus maze tests. European Journal of Pharmacology, 684: 95-101.

21. Quaglio G.L., Pattaro,Gilberto Gerra C., Mattewson S., Verbanck P., Jarlais D.D., Lugoboni F., 2012. High dose benzodiazepine dependence. Description of  29 patients treated with flumazenil infusion and stabilised with clonazepam. Psychiatry Research, 198:457-462.  

 

22. Skerritt J.H., Johnson G.A.R., 1983. Enhancement of GABA binding by benzodiazepineand related anxiolytics. European Journal of Pharmacology, 89: 193-198.

23. Soheili Kashani M., Salami M., Rezaie-Tavirani M., Talaei Zavareh S.A., 2010. Maze training improves learning in an Alzheimer model of rat. Journal of Kashan University of Medical Science, 20.

24. Tang M., Plaessmann W.R., Falk J.L., 1988. The role of central and peripheral type benzodiazepine receptors in anxiolytic agent augmentation of NaCl solution intake: Effect of clonazepam and Ro5-4864. Pharmacology Biochemistry and Behavior, 30: 749-752.

25. Uffett-Jerrott S.E., Stewart S.H., 2002. Cognitive and sedative effects of benzodiazepine use. Current Pharmacological Design, 8: 45-58.

26. Venault P., Chapoutier G., Decarvalhol P., Simiand G., Morre M., Dodd R.H., 1986. Benzodiazepine impairs and betacarboline enhances performance in learning and memory tasks. Nature, 321: 860-864.