The Effects of Oil Extracted of Ricinus communis (Castor Oil Plant) on the Treatment of Gastritic Ulcer Induced by Acetic Acid in Male Rats

Subject Areas : Journal of Animal Biology

M. Azarshab ¹ , gholamhassan vaezi ² , M. Rahnama ³

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Biology, Zanjan Branch, Islamic Azad University, zanjan, Iran

Received: 2017-06-17 Accepted : 2017-06-17 Published : 2017-05-22

Keywords: Rats, Gastric ulcer, Oil of ricinus,

Abstract :

Gastric ulcer is a benign disease in the digestion system caused by a small ulcer in the mucus layer of stomach. One of the ways to cure ulcer is using medicinal herbs. The medicinal herb, helpful in curing the gastric, is Ricinus communis. Its oil is antibacterial, antivirus and antifungal. It contains ricin oil, antioxidant, tanen and vitamin A, E and C that reduces inflammation of the ulcer. In this investigation, 60 male rats weighing 240-280 gr were provided. They were divided into 8 groups randomly, each including 12 rats. Control, sham and experiment group 1, 2, 3 with 50, 100, 200 mg/kg for Ricinus rats were not fed 48 h, 2h given water before surgery. Gastric was caused by injecting acetic acid to where there were no vessels. One day after causing the gastric, oil was given to the rats through gavage tube with different doses. The rats were killed in the day 4, 7, 10 and 14, and their stomachs were extracted and the dimensions of ulcer calculated based on millimeter square. After cutting samples and providing Lam with hematoxylin and eosin stain the percentage of recovery in oil of Ricinus in three doses (50, 100, 200 mg/kg) in the day 4, 7, 10 and 14 had a meaningful increase in comparison with Sham and control group (P<0.05).

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