Investigating the effect of two weeks of Q10 supplementation on troponins I and T in male rats for its inhibitory activity
Subject Areas : Journal of Animal BiologyMoghgan gudarzi 1 , mania roozbayani 2 , vahid valipoor dehno 3 , Reza Goodarzi 4
1 - Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2 - Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran
3 - Department of Physical Education, Lorestsn University, Khorramabad, Iran
4 - Department of Agriculture, Borujerd Branch, Islamic Azad University, Borujerd, Iran
Keywords: coenzyme Q10, troponin I, troponin T, inhibitory activity,
Abstract :
Performing intense exercise activities is associated with an increase in oxidizing substances in the body, which can cause damage to the heart tissue, and subsequently, the level of troponins I and T increases. In such cases, taking nutritional supplements such as coenzyme Q10 can probably prevent these injuries. However, no comprehensive studies have been conducted regarding the effects of this food item on the indicators of heart damage following sports activities. For this purpose, 40 8-week-old male Wistar rats with an average weight of 239.48+6.7 grams were randomly divided into 4 groups: placebo, placebo + acute activity, supplement and supplement + acute activity. The supplement groups received 0.02 ml of Q10 supplement per day for two weeks by gavage. The acute activity groups also performed the activity of swimming in water until exhaustion after the completion of the supplemental period. 2 hours after the acute activity, blood samples were taken from the hearts of mice to measure troponin I and T proteins, and then plasma samples were prepared. One-way ANOVA test showed that troponin I and T increased significantly after exercise in both groups compared to before exercise (p=0.000). Also, the results showed that the consumption of Q10 causes a significant decrease in troponin I (p=0.000) and troponin T (p=0.019) compared to the placebo group in response to the inhibitory activity. Based on the results obtained from the present study, two-week supplementation of coenzyme Q10 may be able to reduce the damage caused to the rat's heart due to the activity of the inhibitor.
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