Investigating the effect of two weeks of Q10 supplementation on troponins I and T in male rats for its inhibitory activity
Subject Areas : Journal of Animal Biology
Moghgan gudarzi
1
(Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran)
mania roozbayani
2
(Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran)
vahid valipoor dehno
3
(Department of Physical Education, Lorestsn University, Khorramabad, Iran)
Reza Goodarzi
4
(Department of Agriculture, Borujerd Branch, Islamic Azad University, Borujerd, Iran)
Keywords: coenzyme Q10, troponin I, troponin T, inhibitory activity,
Abstract :
Performing intense exercise activities is associated with an increase in oxidizing substances in the body, which can cause damage to the heart tissue, and subsequently, the level of troponins I and T increases. In such cases, taking nutritional supplements such as coenzyme Q10 can probably prevent these injuries. However, no comprehensive studies have been conducted regarding the effects of this food item on the indicators of heart damage following sports activities. For this purpose, 40 8-week-old male Wistar rats with an average weight of 239.48+6.7 grams were randomly divided into 4 groups: placebo, placebo + acute activity, supplement and supplement + acute activity. The supplement groups received 0.02 ml of Q10 supplement per day for two weeks by gavage. The acute activity groups also performed the activity of swimming in water until exhaustion after the completion of the supplemental period. 2 hours after the acute activity, blood samples were taken from the hearts of mice to measure troponin I and T proteins, and then plasma samples were prepared. One-way ANOVA test showed that troponin I and T increased significantly after exercise in both groups compared to before exercise (p=0.000). Also, the results showed that the consumption of Q10 causes a significant decrease in troponin I (p=0.000) and troponin T (p=0.019) compared to the placebo group in response to the inhibitory activity. Based on the results obtained from the present study, two-week supplementation of coenzyme Q10 may be able to reduce the damage caused to the rat's heart due to the activity of the inhibitor.
1. Abdi A., Nasiri M., Abbasi A. 2017. The effects of a session wrestling match with beta-alanine supplementation on some indicators of heart damage in elite wrestlers. Metabolism and Exercise, 7(1):83-93.
2. Ahmadi A., Niknejad A.A., Habibian M. 2021. Comparison of effect of acute endurance and resistance training at different intensity on the levels of cardiac Troponin T and tumor necrosis factor alpha levels in trained men. Journal of Gorgan University of Medical Sciences, 22(4):70-77.
3. Awad A.M., Bradley M.C., Fernández-del-Río L., Nag A., Tsui H.S., Clarke C.F. 2018. Coenzyme Q10 deficiencies: pathways in yeast and humans. Essays in Biochemistry, 62(3):361-376.
4. Binayi F., Joukar S., Najafipour H., Karimi A., Abdollahi F., Masumi Y. 2016. The effects of nandrolone decanoate along with prolonged low-intensity exercise on susceptibility to ventricular arrhythmias. Cardiovascular Toxicology, 16:23-33.
5. Bohm P., Scharhag J., Meyer T. 2016. Data from a nationwide registry on sports-related sudden cardiac deaths in Germany. European Journal of Preventive Cardiology, 23(6):649-656.
6. Borekova M, Hojerova J, Koprda V, Bauerova K. 2008. Nourishing and health benefits of coenzyme Q10. Czech Journal of Food Sciences, 26(4):229.
7. Crane FL. 1989. Comments on the discovery of coenzyme Q: a commentary on “Isolation of a quinone from beef heart mitochondria’by FL Crane, Y. Hatefi, RL Lester and C. Widmer Biochimica Biophysica Acta, 25(1957):220–221. Biochimica et Biophysica Acta (BBA)-General Subjects, 1000:358-363.
8. Eijsvogels T., George K., Shave R., Gaze D., Levine B.D., Hopman M.T. 2010. Effect of prolonged walking on cardiac troponin levels. The American Journal of Cardiology, 105(2):267-72.
9. Esteki S., Ebrahim K., Gholami M., Jalalian R. 2018. The effect of cardiac rehabilitation and coenzyme q10 supplementation on functional capacity and ejection fraction in patients with heart failure. Medical Journal of Mashhad University of Medical Sciences, 60(6):756-766.
10. Gholnari T., Aghadavod E., Soleimani A., Hamidi G.A., Sharifi N., Asemi Z. 2018. The effects of coenzyme Q10 supplementation on glucose metabolism, lipid profiles, inflammation, and oxidative stress in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial. Journal of the American College of Nutrition, 37(3):188-193.
11. Goudarzi Z., Sohrabvandi S., Hashemiravan M., Mortazavian AM. 2013. Evaluation of coenzyme Q10 addition and storage temperature on some physicochemical and organoleptic properties of pomegranate juice. Archives of Advances in Biosciences,4(4).
12. Khanvari T., Sardari F., Rezaei B. 2020. The Effect of 14 Days of Coenzyme Q10 Supplementation on Muscle Damage and Fatigue Indices Following a Bout Exhausting Exercise Activity in Passive Men. Journal of Arak University of Medical Sciences, 23(3):386-397.
13. Kon M., Tanabe K., Akimoto T., Kimura F., Tanimura Y., Shimizu K. 2008. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. British Journal of Nutrition, 10(4):900-903.
14. Kon M., Kimura F., Akimoto T., Tanabe K., Murase Y., Ikemune S., et al. 2007. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exercise Immunological Review, 13:76-88.
15. Kong Z., Nie J., Lin H., George K., Zhao G., Zhang H., et al. 2017. Sex differences in release of cardiac troponin T after endurance exercise. Biomarkers, 22(3-4):345-350.
16. Le Goff C., Kaux J.F., Goffaux S., Cavalier E. 2015. Cardiac biomarkers and cycling race. Journal of Sports Science and Medicine, 14(2):475.
17. Lippi G., Banfi G. 2010. Exercise-related increase of cardiac troponin release in sports: An apparent paradox finally elucidated? Clinica Chimica Acta, 411(7-8):610-611.
18. Lippi G., Impellizzeri F., Salvagno G.L., Mion M., Zaninotto M., Cervellin G., et al. 2010. Kinetics of highly sensitive troponin I and T after eccentric exercise. Clinical Chemistry and Laboratory Medicine, 48(11):1677-1679.
19. McLean AS, Huang SJ. 2010. Biomarkers of cardiac injury. Biomarkers: In Medicine, Drug Discovery, and Environmental Health, 4:119-155.
20. Modir M., Daryanoosh F., Tanideh N., Mohamadi M., Firouzmand H. 2014. The effects of short and middle times aerobic exercise with high intensities on ingredients antioxidant in female Sprague Dawley rats. Medical Journal of Mashhad University of Medical Sciences, 57(3):587-595.
21. Omland T., Aakre K.M. 2019. Cardiac troponin increase after endurance exercise: a new marker of cardiovascular risk? American Heart Association, 140:815-818.
22. Passaglia D.G., Emed L.G.M., Barberato S.H., Guerios S.T., Moser A.I., Silva M.M.F., et al. 2013. Acute effects of prolonged physical exercise: evaluation after a twenty-four-hour ultramarathon. Arquivos brasileiros de cardiologia, 100:21-28.
21. Rahnama N., Faramarzi M., Gaeini A.A. 2011. Effects of intermittent exercise on cardiac troponin I and creatine kinase-MB. International Journal of Preventive Medicine, 2(1):20-23.
22. Ranjbar R., Ahmadi M.A., Zar A., Krustrup P. 2017. Acute effect of intermittent and continuous aerobic exercise on release of cardiac troponin T in sedentary men. International Journal of Cardiology, 236:493-497.
23. Schmied C., Borjesson M. 2014. Sudden cardiac death in athletes. Journal of Internal Medicine, 275:93-103.
24. Shave R., Baggish A., George K., Wood M., Scharhag J., Whyte G. 2010. Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications. Journal of the American College of Cardiology, 56(3):169-176.
25. Shave R., Ross P., Low D., George K., Gaze D. 2010. Cardiac troponin I is released following high-intensity short-duration exercise in healthy humans. International Journal of Cardiology, 145(2):337-339.