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Manuscript ID : ASCIJ-2207-1405 (R1) Visit : 286 Page: 121 - 136

10.22034/ascij.2022.1963966.1405

Article Type: Original Research

Evaluation of the Protective Effects of the Hydroalcoholic Extract of Securigera Securidaca L. Seeds on Alterations of Serum Biochemical Parameters and Renal Indices in Tamsulosin-Treated Male Rats

Subject Areas : Journal of Animal Biology

Sadigheh Khezri Motlagh 1 , Mokhtar Mokhtari 2 , Mehrdad Shariati 3

1 - Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2 - Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
3 - Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran

Received: 2022-07-24 Accepted : 2022-12-26 Published : 2023-05-22

Keywords: Rat, kidney, Lipid, tamsulosin, Securigera securidaca L,

Abstract :

Securigera securidaca L. seeds are rich in polyphenols and flavonoids that have many biological effects. The aim of this study was to evaluate the protective effects of hydroalcoholic extract of Securigera securidaca seed on alterations in serum biochemical parameters including glucose, lipid profile (cholesterol, triglyceride, LDL and HDL), renal function indices (creatinine and BUN) and antioxidant enzymes activity (Catalase, superoxide dismutase, and glutathione peroxidase) in tamsulosin-treated male rats. Seventy-two adult male rats were grouped into 9 groups of 8. The control group did not receive drug treatment but the sham group received 1 ml of extract solvent, the positive control group received 0.4 mg/kg Tamsulosin, negative control groups 1, 2, and 3 received 200, 400, and 800 mg/kg extract, respectively and experimental groups 1, 2 and 3 first received 0.4 mg/kg Tamsulosin and then 200, 400 and 800 mg/kg of extract for 28 days, respectively. Finally, blood samples were collected to measure the serum biochemical parameters. Tamsulosin increased the levels of glucose, creatinine and BUN, and decreased the level of antioxidant enzymes activity in the control group (p < 0.05), but did not cause significant changes in the level of lipid profile (p > 0.05). However, treatment with doses of 400 and 800 mg/kg of extract in experimental groups 2 and 3, improved glucose, creatinine, BUN and antioxidant enzymes activity compared to the control group (p < 0.05). Hydroalcoholic extract of Securigera securidaca seeds can improve changes in biochemical parameters and renal function indices in the serum of tamsulosin-treated male rats.

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