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Manuscript ID : ASCIJ-2305-1492 (R1) Visit : 161 Page: 243 - 262

10.22034/ascij.2023.1986190.1492

Article Type: Original Research

Recent Biotechnological Advances in the Preparation of Wound Dressings for Diabetics

Subject Areas : Journal of Animal Biology

Sayed Rasoul Zaker 1 (Research Center for Natural and Biopharmaceutical Products, University of Isfahan, Isfahan, Iran)
Shahrbanoo Jafari 2 (Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran)
Rahman Emamzadeh 3 (Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran)

Received: 2023-04-14 Accepted : 2023-06-02 Published : 2024-02-20

Keywords: Biotechnology, Drug delivery system, Diabetic Foot Ulcer, Natural polymers, Advanced wound dressing,

Abstract :

In the last two decades, given the importance of biotechnological drugs and their important role in the treatment of chronic wounds, studies have predicted that the market for advanced wound care targeting surgical wounds and chronic wounds is likely to reach $15-22 billion by 2024. Therefore, in the present study, the recent advances in biotechnology in the field of preparing wound dressings from compounds obtained from plants and animals for people with diabetic foot ulcers have been discussed. In this research, the methods and approaches of delivery of therapeutic agents for the treatment of DFUs and in fact the recent results of in vitro and in vivo studies, emphasizing the unique potential of wound dressings based on natural polymers in the treatment of DFUs, have been collected and analyzed. This expansion is expected to be driven by advances in technology, increased incidence of chronic wounds, and an increasing elderly population. A review of the challenges ahead in the treatment of chronic wounds reveals the inadequacy of the effectiveness of some wound care products, suggesting that families and governments must contend with medical challenges for longer periods. Diabetic foot ulcer (DFIU) is a chronic ulcer that can cause severe infections and even amputation. Biomaterials that are currently used as matrices for wound healing can be classified into natural and synthetic types according to their origin. Natural biomaterials such as chitosan, alginate, cellulose, hyaluronic acid, silk fibroin, and collagen have been widely recommended for diabetic foot wound healing due to their easy degradability, remarkable biocompatibility, reduced inflammatory responses, and non-immunogenic nature. Biotechnology guarantees the possibility of using natural biomaterials to develop advanced wound dressings with appropriate and patient-friendly therapeutic results. 

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