The Effect of Six Weeks Aerobic Training and Cinnamon Extract on IL-6 Gene Expression in Fat Tissue of Obese Male Feed by High Fat Diet
Subject Areas : Journal of Animal BiologyAmin Rigi 1 , Tahereh Bagherpoor 2 , Nematollah Nemati 3
1 - Department of Sport Sience, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Sport Sience, Damghan Branch, Islamic Azad University, Damghan, Iran
3 - Department of Sport Sience, Damghan Branch, Islamic Azad University, Damghan, Iran
Keywords: Sports, IL-6, High fat diet, Cinnamom, Obese,
Abstract :
Comparing the concurrent training order on plasma IL-6 levels in elderly male. Introduction: This study aimed to investigate the comparison of a different orders of concurrent training on plasma IL-6 levels, insulin resistance index (HOMA) and anthropometric characteristics of an elderly male. Forty women with 55-70-year-old which having no particular illnesses were divided into 4 groups: endurance-resistance, (n = 9), resistance-endurance (n = 10), interval resistance-endurance (n = 12) training, and control group (n = 9) randomly. Height, weight, BMI, WHR, and serum levels of myonectine glucose and insulin were measured and recorded before and after performing protocol. Experimental groups participated in concurrent training for 8 weeks, 3 sessions every week, 60 minutes in every session. A univariate (covariance) test was used for analyzing the data. A significant increase of vaspin (p < /em> = 0.009) and the significant decrease of glucose (p < /em> = 0.001) and HOMA index (p < /em> = 0.028) was observed in the experimental groups compared to control, no significant difference among experimental groups. There was not any significant difference among groups in insulin levels (p < /em> = 0.37). Older males can take advantage of the concurrent training with any orders of them.
- Badalzadeh, R., Shaghaghi, M., Mohammadi, M., Dehghan, G., Mohammadi, Z. 2014. The effect of cinnamon extract and long-term aerobic training on heart function, biochemical alterations and lipid profile following exhaustive exercise in male rats. Coronary Artery Disease, 2014: 2-8.
- Bray, G.A. 2003. Contemporary diagnosis and management of obesity: Handbooks in Health Care.
- Carey A.L., Steinberg, G.R., Macaulay, S.L., Thomas, W.G., Holmes, A.G., Ramm, G., 2006. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes, 55(10): 2688-2697.
- Chao, L.K., Hua, K.F., Hsu, H.Y., Cheng, S.S., Liu, J.Y., Chang, S.T. 2005. Study on the anti-inflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. Journal of Agricultural and Food Chemistry, 53(18):7274-7278.
- Church, T.S., Thomas, D.M., Tudor-Locke, C., Katzmarzyk, P.T., Earnest, C.P., Rodarte, R.Q., 2011. Trends over 5 decades in US occupation-related physical activity and their association with obesity. PloS One, 6(5): e19657.
- Da Cunha Nascimento, D., de Sousa, N.M.F., de Sousa Neto, I.V., Tibana, R.A., de Souza, V.C., Vieira, D.C.L., 2015. Classification of pro-inflammatory status for interleukin-6 affects relative muscle strength in obese elderly women. Aging Clinical and Experimental Research, 27(6): 791-797.
- Ebrahimi, M., Khenar Sanami, S. 2015. Effects of high fat diet and high intensity aerobic training on interleukin 6 plasma levels in rats. Modares Journal of Medical Sciences: Pathobiology, 18(3): 110-116.
- Eckel, R.H., Grundy, S.M., Zimmet, P.Z., 2005. The metabolic syndrome. The Lancet, 365(9468):1415-1428.
- Eftekhari, E., Zafari, A., Gholami, M., 2016. Physical activity, lipid profiles and leptin. The Journal of Sports Medicine and Physical Fitness, 56(4): 465-469.
- Fairburn, C.G., Walsh, B.T., 2002. Atypical eating disorders (eating disorder not otherwise specified). Eating Disorders and Obesity: A Comprehensive Handbook, 2: 171-177.
- Flegal, K.M., Graubard, B.I. 2009. Estimates of excess deaths associated with body mass index and other anthropometric variables. The American Journal of Clinical Nutrition, 89(4): 1213-1219.
- Gadina, M., Hilton, D., Johnston, J.A., Morinobu, A., Lighvani, A., Zhou, Y-J., 2001. signaling by type I and II cytokine receptors: ten years after. Current Opinion in Immunology, 13(3): 363-373.
- Hasani-Ranjbar, S., Nayebi, N., Larijani, B., Abdollahi, M. 2009. A systematic review of the efficacy and safety herbal medicine used in the treatment of obesity. World Journal of Gastroenterology, 15(25): 3073.
- Kumanogoh, A., Ogata, M. 2010. The study of cytokines by Japanese researchers: a historical perspective. International Immunology, 22(5): 341-345.
- Liuzzi, J.P., Lichten, L.A., Rivera, S., Blanchard, R.K., Aydemir, T.B., Knutson, M.D., 2005. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proceeding of the National Academy of Sciences of the United State of America, 102(19): 6843-6848.
- Loos, R.J., 2012. Genetic determinant of common obesity and their value in prediction. Best Practice and Research Clinical Endocrinology and Metabolism, 26(2):211-226.
- Lukaszewicz, M., Mroczko, B., Szmitkowski, M. 2007. Clinical significance of interleukin-6 (IL-6) as a prognostic factor of cancer disease. Polish Archives of Internal Medicine, 117(5-6): 247-251.
- Mathew, S., Abraham, T.E. 2006. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extract, through various in vitro models. Food Chemistry, 94(4): 520-528.
- Mohammadifar, Sh. 2010. The origin, history and trade routes cinnamon. History of Science, 9: 37-51.
- Mojtaba, E., Sohaily, S., Parsian, H., Zand, A. 2011. Pro-inflammatory cytokine Interleukin-1 beta is associated with cardiovascular fitness in sedentary diabetic patients. Journal of Biodiversity and Environmental Sciences, 1(2): 37-44.
- Mollazadeh, H., Hosseinzadeh, H. 2016. Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iranian Journal of Basic and Medical Sciences, 19: 1258-1270.
- Na, Y.K., Hong, H.S., Lee, W.K., Kim, D.S. 2015. Increased methylation of interleukin 6 gene is associated with obesity in Korean women. Molecular and Cells, 38(5): 452-456.
- Nasery, L., Zafari, A., Banaeifar, A. A., 2015. The response of leptin and lipid parameters related to an aerobic exercise among young athlete and non-athlete womwn. Indian Journal of Fundamental and Applied Life Sciences, 5(S3): 788-798.
- Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pederson, B.K. 2004. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. The Journal of Clinical Investigation, 113(9): 1271-1276.
- Nguyen, N.T., Magno, C.P., Lane, K.t., Hinojosa, M.W., Lane, J.S. 2008. Association of hypertension, diabetes, dyslipidemia, and metabolic syndrome with obesity: finding from the National Health and Nutrition Examination Survey, 1999 to 2004. Journal of the American College of Surgeon, 207(6): 928-934.
- Ossanloo, P., Najar, L., Zafari, A. 2012. The Effects of Combined Training (Aerobic Dance, Step Exercise and Resistance Training) on Body Fat Percent and Lipid Profiles in Sedentary Females of AL_ZAHRA University, European Journal of Experimental Biology, 2(5):1598-1602.
- Ouchi, N., Parker, J.L., Lugus, J.J., Walsh, K. 2011. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology, 11(2): 85-97.
- Roussel, A.M., Hininger, I., Benaraba, R., Ziegenfuss, T.N., Anderson, R.A. 2009. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. Journal of the American College of Nutrition, 28(1):16-21.
- Sartorius, T., Peter, A., Schulz, N., Drescher, A., Bergheim, I., Machann, J. 2014. Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity. PloS One, 9(3): e92358.
- Shalaby, M.A., Saifan, H.A. 2014. some pharmacological effects of cinnamon and ginger herbs in obese diabetic rate. Journal of Intercultural Ethnopharmacology, 3(4): 144.
- Sindhu, S., Thomas, R., Shihab, P., Sriraman, D., Behbahani, K., Ahmad, R. 2015. Obesity is a positive modulator of IL-6R and IL-6 expression in the subcutaneous adipose tissue: significance for metabolic inflammation. PloS One, 10(7): e0133494.
- Tanaka, T., Narazaki, M., Kishimoto, T. 2014. IL-6 in inflammation, immunity, and disease. Cold Spring Harbor Perspective in Biology, 6(10): a016295.
- Teixeria, P., Going, S.B., Sardinha, L., Lohman, T.G., 2005. A review of psychosocial pre-treatment predictors of weight control. Obesity Reviews, 6(1): 43-65.
- Vieira, V.J., Valentine, R.J., Wilund, K.R., Antao, N., Baynard, T., Woods, J.A. 2009. Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. American Journal of Physiology - Endocrinology and Metabolism, 296(5): 1164-1171.
- WHO. 2000. Obesity: preventing and managing the global epidemic, World Health Organization