The Effect of Treadmill Exercise and Curcumin on Catalepsy Reserpine-induced Parkinsonian Male Rat Models
Subject Areas : Journal of Animal Biology
R.
Mohammadi
1
(گروه فیزیولوژی جانوری، واحد قم، دانشگاه آزاد اسلامی، قم، ایران)
رامش احمدی
Ahmadi
2
(گروه فیزیولوژی جانوری، واحد قم، دانشگاه آزاد اسلامی، قم، ایران)
Keywords: Curcumin, Rat, Treadmill exercise, Parkinsons disease,
Abstract :
Parkinson’s disease (PD) is the most common neurologically based movement disorder, clinically diagnosed by the presence of bradykinesia, postural instability, resting tremor and rigidity. Curcumin is a natural polyphenol derived from turmeric that has a neuroprotective role in many neuronal degenerative disorders. Studies indicate that exercise may have beneficial effects on neurodegenerative disorders. Therefore, in the present study, we evaluated the effects of curcumin together with treadmill running on animal model of PD. In this study, 48 Wistar rats were divided in 8 groups (control, curcumin, exercise, Parkinson's disease, Parkinson's disease+ curcumin, Parkinson's disease+ curcumin + exercise, Parkinson's disease+ exercise and curcumin + exercise).Parkinson's disease was induced by injection of reserpine (1mg/kg, i.p) for 2days. The bar-test was used to measure cataleptic symptoms. Each of animals in the curcumin groups was given injection of curcumin (50 mg/kg, i.p) for 21 days. All animals in the exercise group were forced to run on a motorized treadmill (24 m/min for 20 min, 5 day/week), for 3 week. SPSS software was used for analyzing data by using of analysis of variance that it was performed at a significance level of p≤0.05. Catalepsy had no significant difference between the group of curcumin + Parkinson's disease+ exercise and Parkinson's disease+ curcumin and Parkinson's disease+ exercise. curcumin can reduce catalepsy induced by reserpine in male rat's model of Parkinson's disease. But its reducing effect isn't as effect of exercise.