Influence of Ethanol on Amnesia and State-dependent Learning Induced by Scopolamine in Male Mouse
Subject Areas : Journal of Animal Biologyالهام حاجی زاده 1 , شیوا خضری 2 , مرتضی پیری 3
1 - دانشگاه ارومیه، دانشکده علوم، گروه زیست شناسی، ارومیه، ایران
2 - دانشگاه ارومیه، دانشکده علوم، گروه زیست شناسی، ارومیه، ایران
3 - دانشگاه آزاد اسلامی، واحد اردبیل، گروه زیست شناسی، اردبیل، ایران
Keywords: ethanol, Mouse, Elevated Plus-Maze, Scopolamine, State-dependent learning,
Abstract :
Previous studies show that ethanol and scopolamine induce amnesia and state-dependent learning. Based on these findings, in the present study, the effect of ethanol on scopolamine induced amnesia and state-dependent learning has been evaluated in the elevated plus-maze task. In this experimental study we used adult male NMRI mice. Mice were anaesthetized and cannulae implanted bilaterally in the CA1 regions of the dorsal hippocampus using stereotaxic method. Seven days after recovery from surgery, the effect of ethanol on scopolamine amnesia and state dependent learning in mice was examined. Pre-training intra-CA1 injection of scopolamine induced amnesia. Pre-test administration of scopolamine or ethanol restored amnesia induced by pre-training scopolamine. Pre-test injection of ethanol by itself impaired memory but potentiated the reversal effect of pre-test scopolamine on amnesia induced by pre-training scopolamine. These results show that ethanol could influence scopolamine state-dependent learning in the dorsal hippocampus. Furthermore, the data proposed a cross state-dependent learning between ethanol and scopolamine in the mouse dorsal hippocampus.
1- Azami N.S., M. Piri, S. Oryan, M. Jahanshahi, V. Babapour, M.R. Zarrindast (2010), Involvement of dorsal hippocampal alpha-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task. Neurobiology of Learning and Memory, 93(4): 455-62.
2- Bartus R.T. (2000), On neuro degenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Experimental Neurology, 163(2): 495-529.
3- Biala G., M. Kruk (2008), Calcium channel antagonists suppress cross-tolerance to the anxiogenic effects of D-amphetamine and nicotine in the mouse elevated plus maze test. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(1): 54-61.
4- Biala G., M. Kruk (2008), Cannabinoid receptor ligands suppress memory-related effects of nicotine in the elevated plus maze test in mice. Behavioural Brain Research, 192(2): 198-202.
5- Blokland A. (1995), Acetylcholine: a neurotransmitter for learning and memory? Brain Research and Brain Research Review, 21(3): 285-300.
6- Coyle J.T., D.L. Price, M.R. DeLong (1983), Alzheimer's disease: a disorder of cortical cholinergic innervation. Science, 219(4589): 1184-90.
7- Da Cunha I.C., R.F. Jose, L. Orlandi Pereira, J.A. Pimenta, I.A. Oliveira de Souza, R. Reiser, H. Moreno, J. Marino Neto, M.A. Paschoalini, M.S. Faria (2005), The role of nitric oxide in the emotional learning of rats in the plus-maze. Physiology of Behavior, 84(3): 351-8.
8- Fadda P., L. Robinson, W. Fratta, R.G. Pertwee, G. Riedel (2006), Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts. Behavioural Brain Research, 168(2): 307-11.
9- Henn C., K. Loffelholz, J. Klein (1998), Stimulatory and inhibitory effects of ethanol on hippocampal acetylcholine release. Naunyn Schmiedebergs Archives of Pharmacology, 357(6): 640-7.
10- Izquierdo I., R.D. Dias (1983), Memory as a state dependent phenomenon: role of ACTH and epinephrine. Behavioral and Neural Biology, 38(1):144-9.
11- Khakpai F., M. Nasehi, A. Haeri-Rohani, A. Eidi, M.R. Zarrindast (2012), Scopolamine induced memory impairment; possible involvement of NMDA receptor mechanisms of dorsal hippocampus and/or septum. Behavioural Brain Research, 231(1):1-10.
12- Mahmoodi G., S. Ahmadi, A. Pourmotabbed, S. Oryan, M.R. Zarrindast (2010), Inhibitory avoidance memory deficit induced by scopolamine: Interaction of cholinergic and glutamatergic systems in the ventral tegmental area. Neurobiology of Learning and Memory, 94(1):83-90.
13- Melis F., R. Stancampiano, A. Imperato, G. Carta, F. Fadda (1996), Chronic ethanol consumption in rats: correlation between memory performance and hippocampal acetylcholine release in vivo. Neuroscience, 74(1):155-9.
14- Nasehi M., M. Piri, N. Jamali-Raeufy, M.R. Zarrindast (2010), Influence of intracerebral administration of NO agents in dorsal hippocampus (CA1) on cannabinoid state-dependent memory in the step-down passive avoidance test. Physiology of Behavior, 100(4): 297-304.
15- Nguyen P.V., T. Abel, E.R. Kandel (1994), Requirement of a critical period of transcription for induction of a late phase of LTP. Science (New York, NY, 265(5175): 1104-7.
16- Overton D.A. (1978), Basic mechanisms of state-dependent learning. Psychopharmacol Bull, 14(1):67-8.
17- Pakpour B., S. Ahmadi, T. Nayer-Nouri, S. Oryan, M.R. Zarrindast (2010), Inhibitory avoidance memory deficit induced by scopolamine: interaction with glutamatergic system in the nucleus accumbens. Behavioral Pharmacology, 21(8):719-26.
18- Pakpour B., S. Oryan, M. Navaeian, T. Saba, M. Piri (2013), Evaluation of the interaction between NMDA receptors of nucleus accumbens and muscarinic receptors in memory. Journal of Qom Univiversity of Medical Science, 7(1): 1-10.
19- Piri M., A. Moshfegh, S. Oryan, M.R. Zarrindast (2010), Influence of dorsal hippocampal α2-adrenegic receptors on WIN55, 212-2 state-dependent memory of passive avoidance. Journal of Qom Univiversity of Medical Science, 4(3): 29-36 (Persian).
20- Piri M., M.R. Zarrindast (2011), Nitric oxide in the ventral tegmental area is involved in retrieval of inhibitory avoidance memory by nicotine. Neuroscience, 175: 154-161.
21- Rezayof A., S. Alijanpour, M.R. Zarrindast, Y. Rassouli (2008), Ethanol state-dependent memory: involvement of dorsal hippocampal muscarinic and nicotinic receptors. Neurobiology of Learning and Memory, 89(4): 441-447.
22- Rezayof A., T. Motevasseli, Y. Rassouli, M.R. Zarrindast (2007), Dorsal hippocampal dopamine receptors are involved in mediating ethanol state-dependent memory. Life Science, 80(4): 285-292.
23- Rezayof A., K. Sharifi, M.R. Zarrindast, Y. Rassouli (2008), Modulation of ethanol state-dependent learning by dorsal hippocampal NMDA receptors in mice. Alcohol, 42(8): 667-674.
24- Rezayof A., Z. Shirazi-Zand, M.R. Zarrindast, T. Nayer-Nouri (2010), Nicotine improves ethanol-induced memory impairment: the role of dorsal hippocampal NMDA receptors. Life Science, 86(7-8): 260-266.
25- Rezayof A., A. Zare-Chahoki, M.R. Zarrindast, Y. Rassouli (2010), Inhibition of dorsal hippocampal nitric oxide synthesis potentiates ethanol-induced state-dependent memory in mice. Behavioral Brain Research, 209(2): 189-195.
26- Ron D. (2004), Signaling cascades regulating NMDA receptor sensitivity to ethanol. Neuroscientist, 10(4): 325-336.
27- Schummers J., M.D. Browning (2001), Evidence for a role for GABA (A) and NMDA receptors in ethanol inhibition of long-term potentiation. Brain Research and Molecular Brain Research, 94(1-2): 9-14.
28- Shulz D.E., R. Sosnik, V. Ego, S. Haidarliu, E. Ahissar (2000), A neuronal analogue of state-dependent learning. Nature, 403(6769): 549-553.
29- Stancampiano R., M. Carta, S. Cocco, R. Curreli, Z.L. Rossetti, F. Fadda (2004), Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex. Brain Research, 997(1): 128-32.
30- Stancampiano R., S. Cocco, C. Cugusi, L. Sarais, F. Fadda (1999), Serotonin and acetylcholine release response in the rat hippocampus during a spatial memory task. Neuroscience, 89(4): 1135-1143.
31- Watts J., R. Stevens, C. Robinson (1981), Effects of scopolamine on radial maze performance in rats. Physiology of Behavior, 26(5): 845-851.
32- Zarrindast M.R., A. Bakhsha, P. Rostami, B. Shafaghi (2002), Effects of intrahippocampal injection of GABAergic drugs on memory retention of passive avoidance learning in rats. Journal of Psychopharmacology, 16(4): 313-319.
33- Zarrindast M.R., M. Dorrani, R. Lachinani, A. Rezayof (2010), Blockade of dorsal hippocampal dopamine receptors inhibits state-dependent learning induced by cannabinoid receptor agonist in mice. Neuroscience Research, 67(1): 25-32.
34- Zarrindast M.R., A. Rezayof (2004), Morphine state-dependent learning: sensitization and interactions with dopamine receptors. European Journal of Pharmacology, 497(2): 197-204.
_||_