The Analgesic Effect of Dietary Sesame Oil in Young Male Rats

Subject Areas : Journal of Animal Biology

حسین  محمدپورکارگر ¹ (دانشگاه آزاد اسلامی واحد دامغان)
منیره  شفاهی ² (دانشگاه آزاد اسلامی واحد آزاد شهرـ مربی)
مهناز  کسمتی ³ (دانشیار گروه بیولوژی دانشگاه شهید چمران)

Received: 2014-06-23 Accepted : 2017-05-21 Published : 2010-04-21

Keywords: pain, sesame oil, lecithin, Unsaturated fatty, Hot plat test, Formalintest,

Abstract :

Sesame oil is applied in physiological and pharmacological researches as a solvent. It contains unsaturated fatty acids and lecithin. Physiological functions may be altered by these components. In this research, effect of dietary sesame oil on acute pain perception was studied.N-MRI male rats (200andplusmn;20 g) were used. Animals divided to two groups: control that ate plats without sesame oil and experimental group that divided to three subgroups that ate dietary plats that contain 10% sesame oil for 28, 42 and 56 days respectively. After 28, 42 and 56 days pain threshold was tested by digital hot plate and formalin. Data was analyzed by one way ANOVA.Hot plate test: Sesame oil diet decreased pain in the 28 days (Pandlt;0.002) and 42 days (Pandlt;0.03) and 56 days (Pandlt;0.005) significantly. In Formalin test sesame oil diet decreased pain in the 28 days (Pandlt;0.0001) and 42 days (Pandlt;0.0001) and 56 days (Pandlt;0.0003) significantly in early phase and also we found significant difference in 42 days (Pandlt;0.03) and 56 days (Pandlt;0.0005) in late phase of formalin test.Conclusion: Our data showed that dietary sesame oil could increase pain threshold. It seems that sesame oil lecithin (as a source for acetylcholine) or unsaturated fatty acid (altered plasma membrane properties or PGs metabolism or affects on GABAergic) involve in this pain threshold alternation.