Alcoholic Extract of Vitex (Vitexagnus-castus) and vitamin E on Serum Level of Hepatic Enzymes, Glucose, Lipid Profile and Insulin in Adult Female Rats

Subject Areas : Journal of Animal Biology

Z. Nejaty ¹ (گروه زیست شناسی، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران)
S.E. Hosseini ² (گروه زیست شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران)

Received: 2017-01-08 Accepted : 2017-05-21 Published : 2017-01-20

Keywords: vitamin E, insulin, glucose, Lipid profile, ALP, ALT, Vitex,  AST,

Abstract :

Chronic hyperglycemias led to diabetes that was a metabolic disorder caused by a defect in insulin secretion or function with decreased serum levels of vitamin E and the liver damaged.Vitex plant traditionally wasused to treat many diseases. The present study aimed to investigate the effect of Vitex and vitamin-E on serum levels on some hepatic enzyam, glucose, and insulin , lipid profile and weight was performed in rats.Methods: In this study, 40 adult female rats weighing 220 to 250 g in the controls group, and the 3 experimental groups were studied.Each group consisted of 8 mice. The experimental groups 1 weredivided by received 40mg / kg extract of Vitex, empirical 2received 40 mg/kg extract of Vitexand 40mg / kgvitamin E, and empirical 3 received 40 mg/kg vitamin E.Prescription was administered for 14 days, at the end of the fourteenth day, phlebotomizing by inter-ventricular to mice were performed and then by diagnostic kits, serum levels, insulin hormone, glucose, enzymes ALP, ALT and AST was measured. The data by using ANOVA and Tukeytest was analyzed and evaluated. The results showed that ethanol extracts of Vitex and vitamin E have no effect on glucose levels, while significantly caused to decrease the cholesterol, triglycerides, LDL, ALP and AST enzymes, and then increased insulin and HDL.Conclusion:Vitex Extract and Vitamin E due to antioxidant properties led to increased insulin hormone and HDL levels and reduced cholesterol, triglycerides, LDL ALP, AST enzymes.