Development of an Electrochemical Sensor Based on ZnO Nanocomposite and Carbon Nanotubes Modified with Molecularly Imprinted Polymer for Dopamine Detection in Biological Samples
Subject Areas : Nanotechnologie
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Keywords: Dopamine, Electrochemical sensor, ZnO nanocomposite, Carbon nanotubes, Molecularly imprinted polymer,
Abstract :
In this study, a novel electrochemical sensor based on a ZnO nanocomposite and multi-walled carbon nanotubes (MWCNTs) modified with molecularly imprinted polymer (MIP) was designed and fabricated for the selective determination of dopamine in biological samples. ZnO nanoparticles were employed as an effective platform due to their high surface area, good conductivity, and chemical stability to enhance the electrochemical response. Additionally, carbon nanotubes improved electron transfer and increased sensitivity. The molecularly imprinted polymer was synthesized using dopamine as the template molecule to enhance the sensor’s selectivity. The sensor's performance was evaluated using differential pulse voltammetry (DPV). The results demonstrated that the proposed sensor exhibited a low detection limit of 0.08 µM, a wide linear range of 0.1–100 µM, and good repeatability. Moreover, acceptable recovery was observed in real samples such as human serum and urine.
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