Background: Multiple Sclerosis (MS) is a chronic central nervous system disorder that can impair the sensory and motor-nerve system by destroying the myelin sheath. These may lead to fatigue and Quality of Life (QoL). This study investigated the effect of eight-week massage as a complementary therapy on fatigue, Physical Component Health (PhCH), Psychological Component Health (PsCH), and QoL in MS female patients.Methods: In this quasi-experimental study, 20 MS females with EDSS (Expanded Disability Status Score) = 2 – 5 were enrolled. After a briefing and obtaining consent, the subjects were pre-tested. The subjects were randomly divided into Control (n= 10) and experimental (n= 10) groups. The massage therapy was performed for eight-week (two sessions of 30 minutes per week). Fatigue and Quality of Life were assessed at the beginning and end of the protocol using the Modified Fatigue Impact Scale (MFIS) and Quality of Life Short Form Questionnaire (SF-36), respectively.Results: Twenty females MS patients (age= 26-44 yr., weight= 53.-87 Kg, BMI (Body Mass Index) =24. 32 Kg.m-1) completed the study period. Data demonstrated a significant decrease in fatigue (F= 45.38, p= 0.001), a significant increase in PhCH (F= 21.60, P= 0.001), PsCH (F= 5.42, P= 0.001), and QoL (F= 22.67, P= 0.001).Conclusion: Massage can be a non-invasive, safe, low-cost, and complementary intervention to improve fatigue and quality of life in MS patients. Manuscript profile

Background: The corona epidemic reduced physical activity in individuals, which is a determining factor in the physical and mental health of individuals, and is a part of the individual quality of life (QoL). This study had three aims. The first was comparing the Body Mass Index (BMI) and QoL of employees in a government organization before and after the COVID-19 pandemic, second evaluating how the BMI and QoL of the employees were affected by their PA levels (1.5, 3, or more than 4.5 h/w) and their occupation type (OT) (line, staff, or research), and third assess the BMI and QoL of the employees after two years of the COVID-19 pandemic based on their PA levels and OT. Methods: This was a descriptive cross-sectional study, and the statistical population was the employees of a public organization. The data of this study were collected between 1398 and 1400, by using QoL Questionnaire were analyzed. Fifty active subjects (35.26 ±3.06 yr.) participated in this study. The t-test, Wilcoxon, F-test, ANCOVA Wilcoxon) as statistical analysis (P<0.05). Results: In the first stage, significant differences were observed in weight, BMI, and environmental health, and a significant decrease in QoL. In the second stage, a significant increase in mental health was observed in people who had 3 or more than 4.5 h/w of exercise before beginning Corona (p <0.05). The third aim is the environmental health significantly increased (PA) < 4.5 h/w, based on OT in three groups, but a significant decrease in social relationships (OT) in Group S, a decrease in QoL (PA) < 4.5 h/w, and, based on OT in three groups (P<0.05). Conclusion: The findings emphasize the importance of physical activity in maintaining QoL and suggest that individuals should pay attention to performing PA in accordance with environmental conditions. Manuscript profile