Background: This study aimed to assess MOB1A and B gene polymorphisms in patients with oral lichen planus (OLP. Several of premalignant lesions such as, leukoplakia, erythroplakia, oral lichen planus (OLP), and submucosal fibrosis can undergo malignant transformation and lead to oral cancer and non-invasive screening of patients to find those susceptible to SCC before progression to cancer would be highly beneficial.Materials and Methods: This case-control study was conducted on 35 OLP patients and 35 healthy controls presenting to the Oral Medicine Department of Zahedan Dental School 2015 -2017. Unstimulated saliva samples were collected from both groups, and MOB1A and B gene polymorphisms were assessed by polymerase chain reaction (PCR). The two groups were compared by the Chi-square test (alpha=0.05).Results: Two groups had no significant difference in the frequency of T and G alleles for MOB1A gene polymorphisms. (P>0.05) and either two groups had no significant difference in the frequency of A and C alleles for MOB1B gene polymorphism's (P>0.05).Conclusion: The present results showed no significant difference between the case and control groups regarding MOB1A and B gene polymorphisms; thus, MOB1A and B gene polymorphisms do not appear to play a role in the pathogenesis of OLP. Manuscript profile