Brain structure is always the first dam against effect drug delivery to treatment of neurologic disorders. Oxidative stress is a critical condition in the pathogenesis of neurologic disorders. N-acetylcysteine amide(NACA), a lipophilic derives of N-acetylcysteine (NAC) that showed a great potential to treatment of oxidative based disorder especially in the brain. we evaluated 83 publications whose title contain NACA. Cast a glance on all the document which showed NACA has protective effect on toxins-drugs toxicity. Most of the articles reported that NACA is a great therapeutic option for cataracts and eye disorders. Hematologic problem and kidney related disorders is a target for NACA. Then, we focused on the neurological application of NACA. It is well-documented that the bio effects of NACA is mediated by antioxidant properties via –SH group. It is more bioavailable and potent than NAC. is significantly higher than NAC. The lipophilic structure confers promising effect to NACA for brain disorders treatment range from trauma to toxins and neurotransmitter toxicity. Manuscript profile