Hemodynamic forces are felt by the biomechanical receptors of the arterial wall to give an appropriate response to maintain homeostasis. On the other hand, baroreceptors are a type of biomechanical receptors that are sensitive to abnormal stretch sizes. It is very important to predict the distribution of stress and strain caused by the hemodynamic field to the vessel wall in pressure-sensitive areas to evaluate the function of these receptors. In the present study, a three-dimensional (3-D) model of the aortic arch is presented. The geometry was reconstructed based on the CT images. Also, numerical analysis was performed using the fluid-structure interaction method. First, the hemodynamic field containing the pressure and velocity distribution in the blood area was obtained. Then, the deformation and stress fields in the solid domain were analyzed. The results show that the highest vertical stress occurs in the posterior supra aorta. So, the amount of this maximum vertical stress increases up to 5 kPa in some places; these points have higher tensions, and they can be susceptible to rupture and aneurysm diseases. Higher normal stress happened at the aortic root and the supra-aortic branches and reached approximately 200 kPa at Peak Systole. Also, the highest amount of strain occurs in the posterior supra aorta, reaching 0.001. Manuscript profile