In this study, copper oxide (Cu2O) particles were synthesized by octahedral shape and then were loaded with palladium (Pd). Cu2O and Pd/Cu2O, which was prepared by X-ray diffraction (XRD), scanning electron microscopy (SEM)/ Energy-dispersive X-ray spectroscopy (EDS), Brunauer-Emmett-Teller (BET) analysis and Barrett-Joyner-Halenda (BJH), Transmission electron microscopy (TEM) and Diffuse Reflectance Spectroscopy (DRS) methods, was identified. Degradation of Direct Red 278 (DR 278) was investigated by Cu2O and, Pd-Cu2O octahedral. The photocatalytic activity of Cu2O was improved by the loaded Pd. The effect of factors such as pH, time (min), mass of catalyst (g) and concentration (mg/L) was evaluated by central composite design (CCD). Among the factors, pH, mass of catalyst, concentration and time have been affected the degradation process, respectively. The highest efficiency of dye degradation was obtained at optimum conditions with pH = 2.95, mass of catalyst 0.11 (g), concentration 177.56 (mg/L) and time 11.02 (min), 99.99%. Based on the results, Pd/Cu2O octahedral is a very effective catalyst for the destruction of textile effluents. The kinetic study results indicated that pseudo first-order has a good agreement with the experimental data. Manuscript profile