In this study, the antioxidant activity and green synthesis of silver nanoparticles of ethanolic extracted from the seeds of Bunium persicum (Boiss.) B.Fedtsch was investigated for the first time. B.persicum is a local plant of Iran and the antioxidant activity of this plant was studied using the DPPH method and shows notable results in scavenging the free radicals. Antioxidant activity of extract checked in comparison to BHT.IC50 of B.persicum respectively was 1000mg/mL; revealing a notable antioxidant effect. Another experiment was performed on green synthesis of silver nanoparticles in this plant extract. Green synthesis of silver nanoparticles in B. persicum was confirmed by the Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM),UV-Vis spectroscopy, Energy dispersive X-ray diffraction analysis (EDX) and the X-ray diffraction (XRD). Ag NPs were almost spherical in shape, with an average diameter of 51 nm. Results showed significant antioxidant effects that cause the formation of spherical silver nanoparticles with nearly homological size in this plant and can be used as the basis of medical studies in the future. Manuscript profile