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    1 - Characterization of bioactive compounds from <i>Ficus vallis-choudae</i> Delile (Moraceae)
    20.1001.1.25883623.2017.1.4.7.4
    Jean Jules Kezetas Bankeu Amadou Daw&eacute; Marius Mbiantcha Guy Raymond Feuya Iftikhar Ali Marthe Aim&eacute;e Tchuente Tchuenmogne Lateef Mehreen Bruno Lenta Muhammad Ali Augustin Silv&egrave;re Ngouela
    Trends in Phytochemical Research , Issue 4 , Year , Autumn 2017
    Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide n More
    Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of &beta;-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), &beta;-sitosterol (6), and mixture of &beta;-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and &alpha;-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 &micro;g/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 &micro;g/mL while the mixture of 7 and 8 showed the maximum &alpha;-glucosidase inhibition with IC50 value 44.0 &micro;g/mL. All the isolates showed weak chemiluminescence activity. Manuscript profile

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