In this study, our objective was to synthesis a new derivative of alginate, a natural biocompatible, biodegradable and non-toxic biopolymer to improve the gelling mechanism. For this purpose, ethylenediamine (EDA) was coupled to sodium alginate (NaA) in an aqueous-phase reaction using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC-HCl) and N-hydroxy succinimide (NHS) as coupling reagents to synthesis ethylenediamine-grafted amphiphilic sodium alginate-amide derivative (NaA-g-EDA). Synthesized derivative showed no environmental sensitivity but the swelling percentage of hydrogels shows that hydrogels obtained from NaA-g-EDA had higher water absorption compared to non-functionalized sodium alginate. It seems that hydrogels can uptake water more than 100% of their weight but in a slow manner. This character is a perfect property for wound dressing. Biodegradable synthesized hydrogel can be decomposed into non-toxic by-products. The purity and grafting of copolymers were characterized using fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1HNMR), X-ray diffraction (XRD), and elemental analysis (CHNX). These analytical methods confirmed the structure of NaA-g-EDA. Manuscript profile

A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction cycles without any loss of its activities, giving a total turnover number (TON) = 594 and turn over frequency (TOF) = 71 h−1. High yield, little catalyst loading, elimination of solvent, simple workup, recovery and reusability of the catalyst are some of the impressive features of the present method. Manuscript profile