An organic–inorganic hybrid nanocomposite was prepared by immobilizing β-cyclodextrin (β-CD) and amino groups onto mesoporous MCM-41 via surfactant-templated sol-gel procedure and post-modification method. The heterogeneous hybrid nanocomposite, MCM-41-β-CD/NH2, was characterized by SEM, TEM, XRD, TGA, BET and FT-IR. The potential application of this covalently linked basic catalyst was also investigated as an efficient, heterogeneous and recyclable stationary micro-vessel and basic heterogeneous catalyst in Biginelli multicomponent condensation reaction. High yield, high efficiency and reusability are among the advantages of this environmentally friendly method. The nano catalyst can be easily separated from the reaction mixture and reused after washing for several runs without less in activity. Manuscript profile