An efficient, mild and environmentally friendly method was reported for the synthesis of An efficient, mild and environmentally friendly method was reported for the synthesis of pyranopyroles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of catalytic amounts of Methyl imidazolium hydrogen sulfate ([Hmim][HSO4]) as an efficient catalyst. These syntheses were performed via a one-pot four-component condensation in water/ethanol (50%) at 50 ◦C. This method easily provides the coresponding products in good yield and relatively short reaction times. Also the reusability of the catalyst was investigated, the catalyst could be employed four times, although its activity gradually decreased. Manuscript profile

One of the important Multi-component reaction (MCRs) is the synthesis of dihydropyrano chromene derivatives by one-pot reaction. In this research, an inexpensive and effective one pot three component procedure with good yields for the synthesis of dihydro pyrano chromenes is reported. In this method, the synthesis of pyrano chromene derivatives was followed by using 4-hydroxycoumarin, malononitrile and aldehydes in the presence of catalytic amount of nano fluoro apatite doped with Mg and Si (Mg-Si-FA). It should be cited that all reactions were carried out in H2O/EtOH as the solvent under reflux condition and the corresponding products were obtained in good yields and pretty short reaction time. Moreover, the anti-bacterial properties of the present products were studied by determination of their minimum inhibitory concentration (MIC). Manuscript profile

An efficient, mild and environmentally friendly method was developed for the Strecker reaction to synthesize α-aminonitriles in the presence of methyl imidazolium hydrogen sulfate ([Hmim][HSO4]) as an efficient catalyst. These syntheses were performed via a one-pot three-component condensation of aldehydes (or ketones), amines, and trimethylsilyl cyanide under mild and solvent free conditions. Manuscript profile

In the present of methylimidazolium hydrogen sulfate, the synthesis of arylidene heterobicyclic pyrimidinones is studied by condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. Using solvent-free conditions, non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method. Manuscript profile