Diabetes mellitus is one of the most common diseases affecting the endocrine system. The prevalence of diabetes mellitus will be increasing in the human population. It is a metabolic disease characterized by chronic escalation of blood glucose and disrupted metabolism of carbohydrates, fats and proteins. This was an experimental study conducted on 40 male Wistar rats. This study was carried out in 2015 at the Islamic Azad University of Dehdasht. Diabetes was induced in the animals through Streptozotocin (STZ). After three days, blood glucose levels were measured. The rats were diagnosed with diabetes when blood glucose was more than 250. The data were analyzed through SPSS 21. Moreover, the independent t-test was used to examine the relationship between variables. Results of statistical analysis in relation to body weight of rats showed that there was a significant relationship between all groups at P<0.05 except for diabetic group and diabetic group by Prangos ferulacea Butanol extract as well as diabetic group by P. ferulacea butanol extract and diabetic groups by P. ferulacea butanol extract and zinc oxide nanoparticles. Concerning the glucose levels, there was a significant relationship between all groups at P<0.05. When applied as a supplement, zinc oxide nanoparticles and P. ferulacea butanol extract can have anti-diabetic properties, curtailing blood glucose, revealing that nanoparticles can be used in the future as a treatment for diabetes. Manuscript profile

Diabetes is one of the common metabolic disorders whose complications have many health problems for society. This study has been carried out with the aim of investigating the effects of hydroalcoholic extract of cedar (Ziziphus spina-christi)on blood glucose, urea, and total cholesterol in the Wistar race of diabetic rats. Forty rats in the weighting range of 300 to 350 were selected as sample and were classified into four groups: control, control of cedar, diabetic, and diabetic of cedar and after bloodletting from rats, data were analyzed by SPSS23 software. Results showed that at the significance level of p < 0.05, consumption the hydroalcoholic extract of cedar leaf can be effective in reducing blood glucose, urea and total cholesterol. After four weeks with consumption of cedar, blood glucose in the diabetic group reduced from 214 mg.dl-1 to 174 mg.dl-1. After four weeks with consumption of cedar extract, blood urea in the diabetic group reduced from 9.4 mg.dl-1 to 5.3 mg.dl-1. After four weeks with consumption of cedar extract, the total cholesterol in the diabetic reduced from 66.3 mg.dl-1 to 60.5 mg/dl. The results of this research indicate the effects of the cedar leaf extract on blood glucose, urea, and total cholesterol. Manuscript profile