Abstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characterized by FTIR, SEM, and EDX methods. Also, magnetic characterization of the synthesized nanoFe3O4/PVA-SA hydrogel was identified by vibrating sample magnetometer (VSM) method. Then, loading and release of famotidine drug was studied by nano-Fe3O4/PVA-SA hydrogel. The FT-IR results confirmed the formation of nano-Fe3O4/PVA-SA hydrogel. The effects of temperature and pH on the loading and release of famotidine drug in gelatin-polyvinylalcohol magnetic hydrogel were studied. The polyvinyl alcohol-sodium alginate magnetic hydrogel is sensitive to pH and temperature and provides the controlled release of famotidine. The results showed that the highest drug loading was achieved at 37 °C after 6 hours. Farther more, the highest drug release rate was obtained after 6 hours at 37 °C at pH = 2 with 57.95 ppm. Manuscript profile