The present work aims to study the growth alterations, productivity, physiological metabolic activities and some antioxidant enzymes as a result of chemical antagonism of Brassica nigra root extract on tomato plants infected with F solani fungus. When the tomato plant is 20 and 60 days old, the extract of B. nigra root interfering with the fungus had a favorable impact on percentage of germination and some growth parameters of tomato plant. Also, it was observed that the total carbohydrates, protein and chlorophyll a and b were increased for tomato plants treated with the extract alone or overlapping with F. solani in contrast to the control. While a process that antioxidant enzymes uptick in the case of plants infected with the fungus alone. There was a noticeable uptick in the N, P, K, Ca, Mg and Fe content in the infected plants treated with the B. nigra extract at the age of 90 days. The tomato plant productivity and quality of the fruits treated with the B. nigra extract improved, either alone or with the fungus. It was found that B. nigra root extract had a positive effect by increasing the growth criteria, physiological activities, growth, productivity and quality of tomato fruits and mitigating the harmful effect of F. solani fungus on tomato plants. Manuscript profile