Tinospora cordifolia (Willd.) Miers, (Menispermaceae), a glabrous, deciduous and trailing plant found in tropical India, China, Sri Lanka, Bangladesh and Myanmar. It is used to treat anemia, debility, diabetes, diarrhea, dysentery, dyspepsia, fevers, jaundice, rheumatism, urinary and skin diseases and snake bites. Its air-dried stem powder was exhaustively extracted with methanol. The concentrated methanolic extract was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate a variety of new chemical constituents characterized as trans-cinnamoyl 2-n-hexanyl-7-methoxynaphthyl amide (2), trans-cinnamoyl 2-n- pentanyl- 6,7- dimethoxynaphthyl amide (3), trans-cinnamoyl 2-n-octanyl-7-methoxynaphthyl amide (4), β-D-arabinosyl-O-geranilan-10′-oate (5), 4,5,7-trimethoxy-2-naphthol-2-O-α-L- arabinofuranosyl-(2′→1′′)-O-α-L-arabinopyranosyl-2′′-O-pentane (6), 5,7-dimethoxy-2-naphthol-2-O-α-L-arabinopyranosyl-(2′→1′′)-α-L- arabinopyranosyl-2′′-O-decane (7) and 5-hydroxy-4''-methoxy-7- flavanoxy- (7→7'''')- β-O-labdan-1-en-3''''α,19''''-olide-18''''-oic acid (tinolabdenyl flavanone) (8) along with cetyl alcohol (1). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical reactions. Manuscript profile

In the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, twice a day) treatments reduced body weight, serum triglycerides (TG), total cholesterol (TG), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (ALT) levels (p < 0.001). AA, AA1, and thymol (T) treatments also decreased lipids (TG and TC) levels and increased thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) levels in hepatic tissue (p < 0.001). Moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. These results recommend that arq ajwain has a strong protective effect against NAFLD in HFD induced obese rat models. Manuscript profile

Fraxinus excelsior L. (Oleaceae) is used to treat diarrhoea, dysentery, jaundice, joint pain, malaria, sores, swelling and wounds. The leaves of Senna sulfurea (Collad.) H. S. Irwin et Barneby (Leguminosae) are effective to cure blennorrhagia, diabetes, dysentery, gonorrhea and skin diseases. Prosopis cineraria (L.) Druce, (Fabaceae) is taken to alleviate anxiety, asthma, bronchitis, dysentery, dyspepsia, fever, leprosy, leucoderma, muscle tremors, piles, rheumatism and tremors. Our study was planned to isolate chemical constituents of the methanolic extracts obtained from the leaves of F. excelsior, S. sulfurea and P. cineraria and to characterized their structures. The air-dried plant materials were exhaustively extracted with methanol separately in a Soxhlet. The concentrated methanolic extracts were adsorbed on silica gel (60-120 mesh) for the preparation of slurries. The dried slurries were chromatographed over silica gel columns individually packed in petroleum ether. The columns were eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate a variety of phytoconstituents. Phytochemical investigation of the leaves of F. excelsior afforded (Z,Z,Z)-n-tetratriacont-3,5,15-triene (1), n-hexatriacontane (2), (Z,Z,Z)-n-octatriacont-11,13,20-triene (3), phytanic acid (3,7,11,15-tetramethylhexadecanoic acid, 4), 26-hydroxystigmasterol-18-oic acid (5) and α-L-xylose (6). The leaves of S. sulfurea furnished isoliquiritigenin (7) and 4-methoxy-α-L-xylopyranosyl-(3→1′)-O-α-L-4′-methoxyxylopyranoside (di-4-methoxy-α-L-xyloside, 8). The leaves of P. cineraria on subjection to silica gel column chromatography led to isolate glyceryl-1-oleioyl-2-myristioyl-3-O-hydroxydihydrocinnamate (9), 2,3,4-trihydroxybenzyl n-hexadecanyl ether (10) and salicyloyl O-α-D-glucopyranosyl-2′-oleate (11). Their structures were established on the basis of spectral data analysis and chemical reactions. Manuscript profile