In this work, Cu@KF/Clinoptilolite NPs was synthesized using Petasites hybridus rhizome water extract as a simple and efficient green procedure. The obtained catalysts were characterized by XRD, SEM, EDX and TEM analysis. The average particle size diameter of the Cu@KF/Clinoptilolite nanoparticles was approximately 30 nm. The adsorption properties of Cu@KF/Clinoptilolite NPs for the removal of cefixime and 4-NP (4-nitrophenol) from aqueous environment were investigated. Using Petasits hybridus leaves water extract, high performance Cu@KF/Clinoptilolite nanoparticles were created in this study. They were then used in numerous reactions to demonstrate the reusability of the nanocatalyst and serve as an environmentally friendly adsorbent for the removal of cefixime (CFX). Also, the catalytic activity of the green synthesized Cu/KF/CP NPs was evaluated in the reduction of organic pollutants such as 4-NP in water at mild conditions. The results indicated that the biosynthesized NCs have very high and effective catalytic activity for organic pollutants within a short time. Some benefits of this process are the quick reaction time, high product yields, and simplicity of catalyst and product separation. Manuscript profile