A green and efficient one-pot three component reaction of 4-hydroxycoumarin or 1,3-dimethylbarbutyric acid, aryl glyoxals and amides (thioacetamide) has been developed in the presence of BF3- SiO2 nanoparticles in water. This method has several advantages such as high to excellent product yields in short reaction time, atom economy, environment friendly, reusable catalyst and no need for chromatographic separations. Manuscript profile

A highly efficient and general method for the synthesis of aryloylamido coumarinsderivatives by a three-component condensation of 4-hydroxycoumarin or 4-hydroxy-6-methylpyran-1-one, aryl glyoxals and benzamide in the presence of nano silica supported tin(II) chloride as a heterogeneous catalyst is established. In this method, SnCl2/nano SiO2 wasused as green and reusable catalyst. Excellent yields, short reaction times, simple workup,and inexpensiveness and commercially availability of the catalyst are the advantages of thismethod. Manuscript profile