In comprehensive urban development plan, a vision of Tehran has been considered as a world city.Tehran is also considered the regional medical center in the world of Islam in the comprehensive scientific map ofIran. In the era of globalization, medical tourism is a growing market in developing countries and has become one offields of competition in regional development. According to the importance of strategic planning for the developmentof medical tourism in the globalization process, the effect of medical service globalization in the mega city of Tehran,and Tehran's response to the requirements are essential to investigate Tehran as a medical tourism destination. This isa descriptive survey and also an analytical and exploratory study. Quantitative and qualitative methods were employedin this research. Data were collected using in-depth interviews with 20 experts and a Delphi questionnaire. In thefirst step, a desk study was performed and the conceptual model was developed. External (environmental threatsand opportunities) and internal (strengths and weaknesses) factors were analyzed by SWOT matrix. According tothe SWOT matrix, medical tourism industry was in WO and SPACE matrix confirmed the result of the IE matrix.Percent using four strategies calculated and strategies ranked quantitatively by QSPM matrix as follows: i) Marketingand Information System Development, ii) Public Infrastructure Development, iii) Product Development, iv) Human Resource Development. Accordingly, policies were developed.. Manuscript profile