The Effect of Continuous Training with high and moderate Intensity on Plasma Level of Phosphorylated Tau and Insulin Resistance in Type 2 Diabetic Women
Subject Areas : Effect of Physical Activity on Diseases
mahdi babaei
1
,
ali yaghoubi
2
1 - Department of Physical Education and Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 - islamic Azad University
Keywords: Phosphorylated Tau Protein, Insulin Resistance, Type 2 Diabetes, Continuous Training,
Abstract :
Introduction: The purpose of the present study was to assess the effect of eight weeks moderate and high-intensity continuous training on plasma levels of phosphorylated tau protein and insulin resistance in type 2 diabetic women. Materials and Methods: 30 type 2 diabetic women with 50 to 60 year old, were randomly divided into 3 groups including: (1) high intensity continuous training, (2) moderate intensity continuous training and (3) control group. High intensity training group include 30 min with 80% of HR reserve for 8 weeks and moderate intensity training include of 50 min with 55% HR reserve for 8 weeks. Results: The results showed that after 8 weeks of continuous training with high and moderate intensity the insulin resistance in type 2 diabetic women decrease (P-value respectively 0.001 and 0.021). Also there was a significant decrease between high intensity of endurance training decrease plasma levels of phosphorylated tau in type 2 diabetic women(P=0.026) but no significant difference found in phosphorylated tau in moderate intensity group (P=0.097). also results show that phosphorylated tau protein levels in high intensity training was lower than control group (P=0/008), but no significant difference found in phosphorylated tau levels in moderate intensity group versus control and high intensity group (P-value respectively 0.724 and 0.056). Conclusion: These results showed that high intensity continuous training through improving insulin resistance probably can reduce phosphorylated tau levels and can have beneficial effects on CNS of type 2 diabetes.
