Response of NF-кB gene in heart tissue of diabetic rats to regular exercise training and atorvastatin drug
Subject Areas : Effect of Physical Activity on Diseases
maryam Ebrahimi
1
,
Habib Asgharpour
2
,
parvin farzanegy
3
,
reza rezaeeshirazi
4
1 - PhD student of Islamic Azad University, Aliabad Katol Branch.
2 - Department of Physical Education and Sports Sciences, Aliabad katoul , Islamic Azad University, Aliabad katoul, Iran
3 - department of physical education
4 - Islamic Azad University
Keywords: Atorvastatin, diabetic cardiomyopathy, NF-κB, continuous and intermittent training,
Abstract :
Background and purpose: Type 2 diabetes accounts for 90-95% of diabetes cases in the world and its prevalence increases with age. The purpose of this research is to determine the effect of two types of exercise training (continuous and intermittent) with atorvastatin. on the expression of NF-кB gene in heart tissue of diabetic model rats.Materials and methods: In this experimental study, 40 male Wistar rats aged about 6 to 8 weeks were randomly divided into 8 groups: 1) healthy control, 2) diabetic, 3) diabetic+ continuous training, 4) diabetic + intermittent training, 5) diabetic + atorvastatin; 6) diabetic + continuous training + atorstatin, 7) diabetic + intermittent training + atorvastatin and 8) saline. First, the induced diabetes model, then the rats of the training groups of two types of continuous training and intermittently were implemented for 8 weeks. Atorvastatin was injected intraperitoneally in the drug and drug+ training groups daily at a dose of 20 mg per kilogram of body weight.Results: Induction of diabetes led to a significant increase in the expression of NF-κB gene in the heart tissue of rats, and intermittent and continuous exercise and the use of atorvastatin led to a decrease in the expression of NF-κB gene in the heart tissue of diabetic rats compared to the diabetic group.Conclusion: There is a possibility that regular exercise alone and in combination with atorvastatin can prevent the development of diabetic cardiomyopathy through the reduction of NF-κB gene and have a protective effect on the heart.
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