Evaluation of pulse and continues administration of doxycycline on serum biochemical indices in colibacillosis infected broilers

Subject Areas : Veterinary Clinical Pathology

adel  feyzi ¹ (دانشگاه آزاد اسلامی، واحد تبریز، استادیار دانشکده دامپزشکی، گروه علوم درمانگاهی، تبریز، ایران.)
loghman  Ahmadzadeh ² (دانش آموخته دکترای حرفه ای دامپزشکی، گروه علوم درمانگاهی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.)

Received: 2016-05-28 Accepted : 2017-01-07 Published : 2017-01-20

Keywords: Colibacillosis, Doxycycline, Pulse administration, Continues administration, Biochemical indices,

Abstract :

Escherichia coli is one of the most important causes of infection in avian species. To reduce the losses caused by this organism, antimicrobials are widely used in the poultry industry. The aim of this study was to compare pulse and continues administration of doxycycline on the clinical signs, lesions and selected biochemical parameters in colibacillosis infected broilers. The study was performed in a colibacillosis infected broiler farm with two similar houses. In the first group Doxycycline was administrated continuously for 4 days and in the second group it was administrated by pulse method for 4 days and 8 hours daily. After treatment, 20 blood samples were taken from each group, and the amounts of ALT, AST, ALP, total protein and creatinine was evaluated by biochemical tests. Differentiated white blood cell counts were also recorded along with gross lesions and clinical signs. Results indicated that there was a significant difference between the two methods concerning the amounts of AST (p<0.05). Although the amounts of ALT, ALP and creatinine in the continuous group were lower than pulse group, but it was not statistically significant. In the continuous group, WBCs and lymphocytes decreased significantly (p<0.05) while hematocrit, heterophils and eosinophil increased significantly (p<0.05). It was demonstrated that the pulse administration of doxycycline had better outcome in treatment of colibacillosis in comparison to continuous administration. Conflict of interest: None declared.

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