Evaluation of changes in blood antioxidants in dogs with parvovirus infection
Subject Areas :
Veterinary Clinical Pathology
arghavan zarandi
1
(
Graduate of Veterinary Medicine, Faculty of Veterinary Medicine, Tabriz Medical Sciences,
Islamic Azad University, Tabriz, Iran.
)
Bahram Amouoghli Tabrizi
2
(
Associate Professor, Department of Clinical Science, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran.
)
siamak mashhahirafei
3
(
Associate Professor, Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
)
Received: 2022-04-24
Accepted : 2022-09-10
Published : 2022-08-23
Keywords:
blood,
dogs,
antioxidants,
parvovirus,
Abstract :
Canine parvovirus (CPV-1) is a highly contagious viral disease in dogs that usually causes acute gastrointestinal disease in puppies. The disease is more common in dogs aged 6 weeks to 6 months. Antioxidants are compounds that prevent oxidation. Oxidation is a chemical reaction that can produce free radicals, thus leading to chain reactions that may damage the cells of living organisms. Antioxidants such as thiol or ascorbic acid (vitamin C) interrupt these chain reactions. Due to the prevalence of parvovirus in dogs and little research on the effect of antioxidants in controlling or exacerbating the disease, this study was performed to determine the effect of antioxidants in the treatment of this disease. In this study, blood samples were taken from 50 dogs, including 25 dogs with parvovirus disease and 25 healthy dogs with the disease, followed by catalase, glutathione peroxidase, superoxide dismutase, malondialdehyde and total antioxidant capacity. Rendox kit spectrophotometry was measured. Statistical results to t-test method and SPSS software version 23 were analyzed. The results showed that the enzymes of catalase, glutathione peroxidase, superoxide dismutase and total antioxidant capacity in the treatment group compared to the control group had a statistically significant decrease and the amount of malondialdehyde increased statistically (P <0.05). The results show that dogs with parvovirus infection are affected by the antioxidant system, so it should be considered in treatment and prevention.
References:
Aebi, H. (1984). Catalase in vitro. In Methods in enzymology. Academic press, 105: 121-126.
Aiello, S.E., Moses, M.A. and Allen, D.G. (2016). The Merck Veterinary Manual. White Station, NJ, USA: Merck & Company, Incorporated, p: 3325.
Amouoghli Tabrizi, B. and Mohajeri, D. (2015). Protective effects of Crocin on experimental hepatic ischemia-reperfusion injury in the rat. Journal of Veterinary Clinical Pathology, 34(2): 103-116.
Baghooli Kermani, M., Nikrahan, G. and Sadeghi, M. )2019(. The effectiveness of happening training on general health and C-reactive protein in coronary patients. Positive Psychology Research, 5(1): 55-70.
Elsayed, N.M., Kubesy, A.A. and Salem, N.Y. (2020). Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis. Journal of Comparative Clinical Pathology, 29(2): 355-359.
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Greene, C.E. )2012(. Infectious Diseases of the Dog and Cat, 4th ed., St. Louis, MO: Elsevier Saunders, pp: 227.
Harizan, I.M., Khinchi, R.K., Manju, S.K. and Meena, V.K. (2021). Alterations in haemato-biochemical and oxidative stress indices in dogs affected with parvoviral enteritis. The Pharma Innovation Journal, 10(8): 428-431.
Judge, P. (2015). Management of the patient with canine parvovirus enteritis. In Proceedings of the New Zealand Veterinary Nursing Association Annual Conference, pp: 5-11.
Kocaturk, M.E.R.İ.Ç., Martinez, S., Eralp, O., Tvarijonaviciute, A., Ceron, J. and Yilmaz, Z.E.K.İ. (2010). Prognostic value of serum acute‐phase proteins in dogs with parvoviral enteritis. Journal of Small Animal Practice, 51(9): 478-483.
Kocaturk, M.E.R.İ.Ç., Martinez, S., Eralp, O., Tvarijonaviciute, A., Ceron, J. and Yilmaz, Z.E.K.İ. (2010). Prognostic value of serum acute‐phase proteins in dogs with parvoviral enteritis. Journal of Small Animal Practice, 51(9): 478-483.
Kraus, R.J. and Ganther, H.E. (1980). Reaction of cyanide with glutathione peroxidase. Biochemical and Biophysical Research Communications, 96(3(: 1116-1122.
Marieb, E.N. and Keller, S.M. (2017). Essentials of Human Anatomy & Physiology, Global Edition. [e-book].
Nandi, S. and Kumar, M. )2010(. Canine parvovirus: current perspective. Indian Journal of virology, 21(1): 31-44.
Ogbu, K.I., Anene, B.M., Nweze, N.E., Okoro, J.I., Danladi, M. and Ochai, S.O. (2017). Canine Parvovirus: A Review. Internation Journal of Science and Applied Research, 2(2): 74-95.
Panda, D., Patra, R.C., Nandi, S. and Swarup, D. (2009). Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Journal of Research in Veterinary Science, 86(1): 36-42.
Pleban, P.A., Munyani, A. and Beachum, J. (1982). Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes. Journal of Clinical Chemistry, 28(2): 311-316.
Pourbabaki, R., Samiei, S., Khadem, M., Kalantari, S., Beigzadeh, Z. and Shahtaheri, S.J.A. (2021) Review on antioxidant-rich products as protective and therapeutic agents against Chlorpyrifos hepatotoxicity. Iran Occupational Health. 18(1): 114-138.
Prohaska, J.R. and Ganther, H.E. (1977). Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver. Journal of Biochemical and Biophysical Research Communications, 76(2): 437-445.
Sykes, J.E. and Rankin, S.C. (2014). Canine and Feline Infectious Diseases, 1th ed., St. Louis, Mo.: Elsevier, Saunders, pp: 80-160.
Ukwueze, C., Akpan, E.S., Ezeokonkwo, R.C., Nwosuh, C.I. and Anene, B.M. (2020). Haematological, oxidative stress and electrolyte alterations in puppies with canine parvoviral enteritis. Iraqi Journal of Veterinary Sciences, 34(1): 65-69.
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Aebi, H. (1984). Catalase in vitro. In Methods in enzymology. Academic press, 105: 121-126.
Aiello, S.E., Moses, M.A. and Allen, D.G. (2016). The Merck Veterinary Manual. White Station, NJ, USA: Merck & Company, Incorporated, p: 3325.
Amouoghli Tabrizi, B. and Mohajeri, D. (2015). Protective effects of Crocin on experimental hepatic ischemia-reperfusion injury in the rat. Journal of Veterinary Clinical Pathology, 34(2): 103-116.
Baghooli Kermani, M., Nikrahan, G. and Sadeghi, M. )2019(. The effectiveness of happening training on general health and C-reactive protein in coronary patients. Positive Psychology Research, 5(1): 55-70.
Elsayed, N.M., Kubesy, A.A. and Salem, N.Y. (2020). Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis. Journal of Comparative Clinical Pathology, 29(2): 355-359.
Elswick, M. (2017). Disease spotlight: canine parvovirus. Retrieve from www.themeowingvet.com
Ettinger, S.J. and Feldman, E. (2016). Text Book of Internal Medicine, 8th ed., Philadelphia, W.B. Saunders, pp:150-200
Greene, C.E. )2012(. Infectious Diseases of the Dog and Cat, 4th ed., St. Louis, MO: Elsevier Saunders, pp: 227.
Harizan, I.M., Khinchi, R.K., Manju, S.K. and Meena, V.K. (2021). Alterations in haemato-biochemical and oxidative stress indices in dogs affected with parvoviral enteritis. The Pharma Innovation Journal, 10(8): 428-431.
Judge, P. (2015). Management of the patient with canine parvovirus enteritis. In Proceedings of the New Zealand Veterinary Nursing Association Annual Conference, pp: 5-11.
Kocaturk, M.E.R.İ.Ç., Martinez, S., Eralp, O., Tvarijonaviciute, A., Ceron, J. and Yilmaz, Z.E.K.İ. (2010). Prognostic value of serum acute‐phase proteins in dogs with parvoviral enteritis. Journal of Small Animal Practice, 51(9): 478-483.
Kocaturk, M.E.R.İ.Ç., Martinez, S., Eralp, O., Tvarijonaviciute, A., Ceron, J. and Yilmaz, Z.E.K.İ. (2010). Prognostic value of serum acute‐phase proteins in dogs with parvoviral enteritis. Journal of Small Animal Practice, 51(9): 478-483.
Kraus, R.J. and Ganther, H.E. (1980). Reaction of cyanide with glutathione peroxidase. Biochemical and Biophysical Research Communications, 96(3(: 1116-1122.
Marieb, E.N. and Keller, S.M. (2017). Essentials of Human Anatomy & Physiology, Global Edition. [e-book].
Nandi, S. and Kumar, M. )2010(. Canine parvovirus: current perspective. Indian Journal of virology, 21(1): 31-44.
Ogbu, K.I., Anene, B.M., Nweze, N.E., Okoro, J.I., Danladi, M. and Ochai, S.O. (2017). Canine Parvovirus: A Review. Internation Journal of Science and Applied Research, 2(2): 74-95.
Panda, D., Patra, R.C., Nandi, S. and Swarup, D. (2009). Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Journal of Research in Veterinary Science, 86(1): 36-42.
Pleban, P.A., Munyani, A. and Beachum, J. (1982). Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes. Journal of Clinical Chemistry, 28(2): 311-316.
Pourbabaki, R., Samiei, S., Khadem, M., Kalantari, S., Beigzadeh, Z. and Shahtaheri, S.J.A. (2021) Review on antioxidant-rich products as protective and therapeutic agents against Chlorpyrifos hepatotoxicity. Iran Occupational Health. 18(1): 114-138.
Prohaska, J.R. and Ganther, H.E. (1977). Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver. Journal of Biochemical and Biophysical Research Communications, 76(2): 437-445.
Sykes, J.E. and Rankin, S.C. (2014). Canine and Feline Infectious Diseases, 1th ed., St. Louis, Mo.: Elsevier, Saunders, pp: 80-160.
Ukwueze, C., Akpan, E.S., Ezeokonkwo, R.C., Nwosuh, C.I. and Anene, B.M. (2020). Haematological, oxidative stress and electrolyte alterations in puppies with canine parvoviral enteritis. Iraqi Journal of Veterinary Sciences, 34(1): 65-69.
